dc.date.accessioned | 2020-06-17T17:55:41Z | |
dc.date.available | 2020-06-17T17:55:41Z | |
dc.date.created | 2019-04-11T15:48:59Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Kollerud, Ruby Del Risco Ruud, Ellen Haugnes, Hege Sagstuen Cannon-Albright, Lisa A. Thoresen, Magne Nafstad, Per Vlatkovic, Ljiljana Blaasaas, Karl Gerhard Næss, Øyvind Claussen, Bjørgulf . Family history of cancer and risk of paediatric and young adult’s testicular cancer: A Norwegian cohort study. British Journal of Cancer. 2019, 120, 1007-1014 | |
dc.identifier.uri | http://hdl.handle.net/10852/77013 | |
dc.description.abstract | Background
The aim of this study was to examine the association of a family history of cancer with the risk of testicular cancer in young adults.
Methods
This is a prospective cohort study including 1,974,287 males born 1951–2015, of whom 2686 were diagnosed with TC before the age of 30.
Results
A history of TC in male relatives was significantly associated with a diagnosis of TC among children and young adults, including brothers (6.3-fold), sons (4.7-fold), fathers (4.4-fold), paternal uncles (2.0-fold) and maternal uncles (1.9-fold). Individuals with a father diagnosed with a carcinoma or sarcoma showed an elevated risk (1.1-fold and 1.8-fold, respectively). A family history of mesothelioma was positively associated with a risk of TC [(father (2.8-fold), mother (4.6-fold) and maternal uncles and aunt (4.4-fold)]. Elevated risks were also observed when siblings were diagnosed with malignant melanoma (1.4-fold). The risk of TC was also increased when fathers (11.1-fold), paternal (4.9-fold) and maternal uncles and aunts (4.6-fold) were diagnosed with malignant neuroepithelial-tumours.
Conclusion
We found an increased risk of TC among children and young adults with a family history of TC, carcinoma, mesothelioma, sarcoma, malignant melanoma and malignant neuroepithelial tumours. Hereditary cancer syndromes might underlie some of the associations reported in this study. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Family history of cancer and risk of paediatric and young adult’s testicular cancer: A Norwegian cohort study | |
dc.type | Journal article | |
dc.creator.author | Kollerud, Ruby Del Risco | |
dc.creator.author | Ruud, Ellen | |
dc.creator.author | Haugnes, Hege Sagstuen | |
dc.creator.author | Cannon-Albright, Lisa A. | |
dc.creator.author | Thoresen, Magne | |
dc.creator.author | Nafstad, Per | |
dc.creator.author | Vlatkovic, Ljiljana | |
dc.creator.author | Blaasaas, Karl Gerhard | |
dc.creator.author | Næss, Øyvind | |
dc.creator.author | Claussen, Bjørgulf | |
cristin.unitcode | 185,52,14,0 | |
cristin.unitname | Avdeling for samfunnsmedisin og global helse | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1691780 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British Journal of Cancer&rft.volume=120&rft.spage=1007&rft.date=2019 | |
dc.identifier.jtitle | British Journal of Cancer | |
dc.identifier.volume | 120 | |
dc.identifier.issue | 10 | |
dc.identifier.startpage | 1007 | |
dc.identifier.endpage | 1014 | |
dc.identifier.doi | https://doi.org/10.1038/s41416-019-0445-2 | |
dc.identifier.urn | URN:NBN:no-80125 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0007-0920 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/77013/4/s41416-019-0445-2.pdf | |
dc.type.version | PublishedVersion | |