Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
dc.date.accessioned | 2020-05-30T19:59:26Z | |
dc.date.available | 2020-05-30T19:59:26Z | |
dc.date.created | 2019-09-15T14:03:27Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Wang, Heming Lane, Jacqueline M. Jones, Samuel E. Dashti, Hassan S. Ollila, Hanna M. Wood, Andrew R. van Hees, Vincent T. Brumpton, Ben Michael Winsvold, Bendik K S Kantojärvi, Katri Palviainen, Teemu Cade, Brian E. Sofer, Tamar Song, Yanwei Patel, Krunal Anderson, Simon G. Bechtold, David A. Bowden, Jack Emsley, Richard Kyle, Simon D. Little, Max A. Loudon, Andrew S. Scheer, Frank A.J.L. Purcell, Shaun M. Richmond, Rebecca C. Spiegelhalder, Kai Tyrrell, Jessica Zhu, Xiaofeng Hublin, Christer Kaprio, Jaakko A. Kristiansson, Kati Sulkava, Sonja Paunio, Tiina Hveem, Kristian Nielsen, Jonas B. Willer, Cristen J. Zwart, John-Anker Strand, Linn B Frayling, Timothy M. Ray, David Lawlor, Deborah A. Rutter, Martin K. Weedon, Michael N. Redline, Susan Saxena, Richa . Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nature Communications. 2019, 10:3503, 1-12 | |
dc.identifier.uri | http://hdl.handle.net/10852/76559 | |
dc.description.abstract | Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes | |
dc.type | Journal article | |
dc.creator.author | Wang, Heming | |
dc.creator.author | Lane, Jacqueline M. | |
dc.creator.author | Jones, Samuel E. | |
dc.creator.author | Dashti, Hassan S. | |
dc.creator.author | Ollila, Hanna M. | |
dc.creator.author | Wood, Andrew R. | |
dc.creator.author | van Hees, Vincent T. | |
dc.creator.author | Brumpton, Ben Michael | |
dc.creator.author | Winsvold, Bendik K S | |
dc.creator.author | Kantojärvi, Katri | |
dc.creator.author | Palviainen, Teemu | |
dc.creator.author | Cade, Brian E. | |
dc.creator.author | Sofer, Tamar | |
dc.creator.author | Song, Yanwei | |
dc.creator.author | Patel, Krunal | |
dc.creator.author | Anderson, Simon G. | |
dc.creator.author | Bechtold, David A. | |
dc.creator.author | Bowden, Jack | |
dc.creator.author | Emsley, Richard | |
dc.creator.author | Kyle, Simon D. | |
dc.creator.author | Little, Max A. | |
dc.creator.author | Loudon, Andrew S. | |
dc.creator.author | Scheer, Frank A.J.L. | |
dc.creator.author | Purcell, Shaun M. | |
dc.creator.author | Richmond, Rebecca C. | |
dc.creator.author | Spiegelhalder, Kai | |
dc.creator.author | Tyrrell, Jessica | |
dc.creator.author | Zhu, Xiaofeng | |
dc.creator.author | Hublin, Christer | |
dc.creator.author | Kaprio, Jaakko A. | |
dc.creator.author | Kristiansson, Kati | |
dc.creator.author | Sulkava, Sonja | |
dc.creator.author | Paunio, Tiina | |
dc.creator.author | Hveem, Kristian | |
dc.creator.author | Nielsen, Jonas B. | |
dc.creator.author | Willer, Cristen J. | |
dc.creator.author | Zwart, John-Anker | |
dc.creator.author | Strand, Linn B | |
dc.creator.author | Frayling, Timothy M. | |
dc.creator.author | Ray, David | |
dc.creator.author | Lawlor, Deborah A. | |
dc.creator.author | Rutter, Martin K. | |
dc.creator.author | Weedon, Michael N. | |
dc.creator.author | Redline, Susan | |
dc.creator.author | Saxena, Richa | |
cristin.unitcode | 185,53,42,13 | |
cristin.unitname | Nevrologisk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1724804 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=10:3503&rft.spage=1&rft.date=2019 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 10 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-019-11456-7 | |
dc.identifier.urn | URN:NBN:no-79601 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/76559/1/Genome-wide%2Bassociation%2Banalysis%2Bof%2Bself-reported%2Bdaytime%2Bsleepiness%2Bidentifies%2B42%2Bloci%2Bthat%2Bsuggest%2Bbiological%2Bsubtypes.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 3503 | |
dc.relation.project | SKGJ/SKGJ-MED-015 | |
dc.relation.project | NFR/248817 |
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