dc.date.accessioned | 2020-05-29T19:28:49Z | |
dc.date.available | 2020-05-29T19:28:49Z | |
dc.date.created | 2020-01-31T11:10:43Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Raheel, Tayyaba Qureshi Sørensen, Christina Berghuis, Paul Jensen, Vidar Dobszay, Marton B. Farkas, Tamas Dalen, Knut Tomas Guo, Caiying Hassel, Bjørnar Utheim, Tor Paaske Hvalby, Øivind C Hafting, Torkel Harkany, Tibor Fyhn, Marianne Chaudhry, Farrukh Abbas . The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity. Cerebral Cortex. 2019 | |
dc.identifier.uri | http://hdl.handle.net/10852/76472 | |
dc.description.abstract | GABA signaling sustains fundamental brain functions, from nervous system development to the synchronization of population activity and synaptic plasticity. Despite these pivotal features, molecular determinants underscoring the rapid and cell-autonomous replenishment of the vesicular neurotransmitter GABA and its impact on synaptic plasticity remain elusive. Here, we show that genetic disruption of the glutamine transporter Slc38a1 in mice hampers GABA synthesis, modifies synaptic vesicle morphology in GABAergic presynapses and impairs critical period plasticity. We demonstrate that Slc38a1-mediated glutamine transport regulates vesicular GABA content, induces high-frequency membrane oscillations and shapes cortical processing and plasticity. Taken together, this work shows that Slc38a1 is not merely a transporter accumulating glutamine for metabolic purposes, but a key component regulating several neuronal functions. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity | |
dc.type | Journal article | |
dc.creator.author | Raheel, Tayyaba Qureshi | |
dc.creator.author | Sørensen, Christina | |
dc.creator.author | Berghuis, Paul | |
dc.creator.author | Jensen, Vidar | |
dc.creator.author | Dobszay, Marton B. | |
dc.creator.author | Farkas, Tamas | |
dc.creator.author | Dalen, Knut Tomas | |
dc.creator.author | Guo, Caiying | |
dc.creator.author | Hassel, Bjørnar | |
dc.creator.author | Utheim, Tor Paaske | |
dc.creator.author | Hvalby, Øivind C | |
dc.creator.author | Hafting, Torkel | |
dc.creator.author | Harkany, Tibor | |
dc.creator.author | Fyhn, Marianne | |
dc.creator.author | Chaudhry, Farrukh Abbas | |
cristin.unitcode | 185,51,12,57 | |
cristin.unitname | Gliaceller | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1787839 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral Cortex&rft.volume=&rft.spage=&rft.date=2019 | |
dc.identifier.jtitle | Cerebral Cortex | |
dc.identifier.volume | 29 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 5166 | |
dc.identifier.endpage | 5179 | |
dc.identifier.doi | https://doi.org/10.1093/cercor/bhz055 | |
dc.identifier.urn | URN:NBN:no-79573 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1047-3211 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/76472/1/Glutamine%2Btransporter_Chaudhry.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | EC/FP7/ERC-AdG-2015-695136 | |