dc.date.accessioned | 2020-05-23T19:33:07Z | |
dc.date.available | 2020-09-27T22:46:28Z | |
dc.date.created | 2019-11-26T12:10:51Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Rehbinder, Eva Maria Endre, Kim Magnus Advocaat Carlsen, Karin C. Lødrup Asarnoj, Anna Bains, Karen Eline Stensby Berents, Teresa Løvold Carlsen, Kai-Håkon Gudmundsdóttir, Hrefna Katrín Haugen, Guttorm Hedlin, Gunilla Kreyberg, Ina Nordhagen, Live Solveig Nordlund, Björn Schinagl, Carina Madelen Sandvik, Leiv Skjerven, Håvard Ove Söderhäll, Cilla Staff, Anne Cathrine Vettukattil, Muhammad Riyas Værnesbranden, Caren Magdalena Rydland Landrø, Linn Aina Ysland . Predicting skin barrier dysfunction and atopic dermatitis in early infancy. Journal of Allergy and Clinical Immunology: In Practice. 2019, 1-15 | |
dc.identifier.uri | http://hdl.handle.net/10852/76174 | |
dc.description.abstract | Dry skin is associated with increased transepidermal water loss (TEWL), which has been found to precede atopic dermatitis (AD) in childhood. Objective We aimed to identify parental, prenatal, and perinatal predictive factors of dry skin, high TEWL, and AD at 3 months of age, and to determine if dry skin or high TEWL at 3 months can predict AD at 6 months. Methods From the Preventing Atopic Dermatitis and Allergies in children prospective birth cohort study, we included 1150 mother-child pairs. Dry skin, TEWL, and eczema were assessed at 3- and 6-month investigations. Eczema, used as a proxy for AD, was defined as the presence of eczematous lesions, excluding differential diagnoses to AD. High TEWL was defined as TEWL >90th percentile, equaling 11.3 g/m2/h. Potential predictive factors were recorded from electronic questionnaires at 18- and 34-week pregnancy and obstetric charts. Results Significant predictive factors (P < .05) for dry skin at 3 months were delivery >38 gestational weeks and paternal age >37 years; for high TEWL, male sex, birth during winter season, and maternal allergic disease; and for eczema, elective caesarean section, multiparity, and maternal allergic diseases. Dry skin without eczema at 3 months was predictive for eczema at 6 months (adjusted odds ratio: 1.92, 95% confidence interval: 1.21-3.05; P = .005), whereas high TEWL at 3 months was not. Conclusion In early infancy, distinct parental- and pregnancy-related factors were predictive for dry skin, high TEWL, and AD. Dry skin at 3 months of age was predictive for AD 3 months later. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Predicting skin barrier dysfunction and atopic dermatitis in early infancy | |
dc.type | Journal article | |
dc.creator.author | Rehbinder, Eva Maria | |
dc.creator.author | Endre, Kim Magnus Advocaat | |
dc.creator.author | Carlsen, Karin C. Lødrup | |
dc.creator.author | Asarnoj, Anna | |
dc.creator.author | Bains, Karen Eline Stensby | |
dc.creator.author | Berents, Teresa Løvold | |
dc.creator.author | Carlsen, Kai-Håkon | |
dc.creator.author | Gudmundsdóttir, Hrefna Katrín | |
dc.creator.author | Haugen, Guttorm | |
dc.creator.author | Hedlin, Gunilla | |
dc.creator.author | Kreyberg, Ina | |
dc.creator.author | Nordhagen, Live Solveig | |
dc.creator.author | Nordlund, Björn | |
dc.creator.author | Schinagl, Carina Madelen | |
dc.creator.author | Sandvik, Leiv | |
dc.creator.author | Skjerven, Håvard Ove | |
dc.creator.author | Söderhäll, Cilla | |
dc.creator.author | Staff, Anne Cathrine | |
dc.creator.author | Vettukattil, Muhammad Riyas | |
dc.creator.author | Værnesbranden, Caren Magdalena Rydland | |
dc.creator.author | Landrø, Linn Aina Ysland | |
cristin.unitcode | 185,53,48,13 | |
cristin.unitname | Avdeling for hudsykdommer | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1752374 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Allergy and Clinical Immunology: In Practice&rft.volume=&rft.spage=1&rft.date=2019 | |
dc.identifier.jtitle | Journal of Allergy and Clinical Immunology: In Practice | |
dc.identifier.volume | 8 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 664 | |
dc.identifier.endpage | 673.e5 | |
dc.identifier.doi | https://doi.org/10.1016/j.jaip.2019.09.014 | |
dc.identifier.urn | URN:NBN:no-79284 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2213-2198 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/76174/1/Predicting%2Batopic%2Bdermatitis%2BJACI%2BIP%2BRehbinder%2B2019.pdf | |
dc.type.version | AcceptedVersion | |