dc.date.accessioned | 2020-05-23T19:25:31Z | |
dc.date.available | 2020-09-03T22:46:25Z | |
dc.date.created | 2019-10-21T16:51:20Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Elvebakk, Ole Tronstad, Christian Birkeland, Kåre I. Jenssen, Trond Geir Bjørgaas, Marit Ragnhild Rokne Gulseth, Hanne Løvdal Kalvøy, Håvard Høgetveit, Jan Olav Martinsen, Ørjan Grøttem . A multiparameter model for non-invasive detection of hypoglycemia. Physiological Measurement. 2019, 40(8), 1-14 | |
dc.identifier.uri | http://hdl.handle.net/10852/76172 | |
dc.description.abstract | Objective: Severe hypoglycemia is the most serious acute complication for people with type 1 diabetes (T1D). Approximately 25% of people with T1D have impaired ability to recognize impending hypoglycemia, and nocturnal episodes are feared. Approach: We have investigated the use of non-invasive sensors for detection of hypoglycemia based on a mathematical model which combines several sensor measurements to identify physiological responses to hypoglycemia. Data from randomized single-blinded euglycemic and hypoglycemic glucose clamps in 20 participants with T1D and impaired awareness of hypoglycemia was used in the analyses. Main results: Using a sensor combination of sudomotor activity at three skin sites, ECG-derived heart rate and heart rate corrected QT interval, near-infrared and bioimpedance spectroscopy; physiological responses associated with hypoglycemia could be identified with an F1 score accuracy up to 88%. Significance: We present a novel model for identification of non-invasively measurable physiological responses related to hypoglycemia, showing potential for detection of moderate hypoglycemia using a wearable sensor system. | |
dc.language | EN | |
dc.relation.ispartof | Elvebakk, Ole (2019) Hypoglycaemia detection with non-invasive sensors. Doctoral thesis. http://hdl.handle.net/10852/86835 | |
dc.relation.uri | http://hdl.handle.net/10852/86835 | |
dc.title | A multiparameter model for non-invasive detection of hypoglycemia | |
dc.type | Journal article | |
dc.creator.author | Elvebakk, Ole | |
dc.creator.author | Tronstad, Christian | |
dc.creator.author | Birkeland, Kåre I. | |
dc.creator.author | Jenssen, Trond Geir | |
dc.creator.author | Bjørgaas, Marit Ragnhild Rokne | |
dc.creator.author | Gulseth, Hanne Løvdal | |
dc.creator.author | Kalvøy, Håvard | |
dc.creator.author | Høgetveit, Jan Olav | |
dc.creator.author | Martinsen, Ørjan Grøttem | |
cristin.unitcode | 185,53,48,12 | |
cristin.unitname | Avdeling for transplantasjonsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1739238 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Physiological Measurement&rft.volume=40&rft.spage=1&rft.date=2019 | |
dc.identifier.jtitle | Physiological Measurement | |
dc.identifier.volume | 40 | |
dc.identifier.issue | 8 | |
dc.identifier.doi | https://doi.org/10.1088/1361-6579/ab3676 | |
dc.identifier.urn | URN:NBN:no-79288 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0967-3334 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/76172/2/_system_appendPDF_proof_hi.pdf | |
dc.type.version | AcceptedVersion | |
cristin.articleid | 085004 | |