dc.date.accessioned | 2020-05-18T18:50:16Z | |
dc.date.available | 2020-05-18T18:50:16Z | |
dc.date.created | 2019-11-26T12:51:09Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Carm, Kristina Totland Hoff, Andreas Midbøe Bakken, Anne Cathrine Axcrona, Ulrika Axcrona, Karol Lothe, Ragnhild A Skotheim, Rolf I. Løvf, Marthe . Interfocal heterogeneity challenges the clinical usefulness of molecular classification of primary prostate cancer. Scientific Reports. 2019, 9(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/75891 | |
dc.description.abstract | Prostate cancer is a highly heterogeneous disease and typically multiple distinct cancer foci are present at primary diagnosis. Molecular classification of prostate cancer can potentially aid the precision of diagnosis and treatment. A promising genomic classifier was published by The Cancer Genome Atlas (TCGA), successfully classifying 74% of primary prostate cancers into seven groups based on one cancer sample per patient. Here, we explore the clinical usefulness of this classification by testing the classifier’s performance in a multifocal context. We analyzed 106 cancer samples from 85 distinct cancer foci within 39 patients. By somatic mutation data from whole-exome sequencing and targeted qualitative and quantitative gene expression assays, 31% of the patients were uniquely classified into one of the seven TCGA classes. Further, different samples from the same focus had conflicting classification in 12% of the foci. In conclusion, the level of both intra- and interfocal heterogeneity is extensive and must be taken into consideration in the development of clinically useful molecular classification of primary prostate cancer. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Interfocal heterogeneity challenges the clinical usefulness of molecular classification of primary prostate cancer | |
dc.type | Journal article | |
dc.creator.author | Carm, Kristina Totland | |
dc.creator.author | Hoff, Andreas Midbøe | |
dc.creator.author | Bakken, Anne Cathrine | |
dc.creator.author | Axcrona, Ulrika | |
dc.creator.author | Axcrona, Karol | |
dc.creator.author | Lothe, Ragnhild A | |
dc.creator.author | Skotheim, Rolf I. | |
dc.creator.author | Løvf, Marthe | |
cristin.unitcode | 185,15,29,40 | |
cristin.unitname | Seksjon for biokjemi og molekylærbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1752407 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=9&rft.spage=&rft.date=2019 | |
dc.identifier.jtitle | Scientific Reports | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 1 | |
dc.identifier.pagecount | 6 | |
dc.identifier.doi | https://doi.org/10.1038/s41598-019-49964-7 | |
dc.identifier.urn | URN:NBN:no-78976 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2045-2322 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/75891/1/Carm_et_al_SciRep_2019.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 13579 | |
dc.relation.project | NOTUR/NORSTORE/NS9013S | |