dc.date.accessioned | 2020-05-09T18:13:25Z | |
dc.date.available | 2020-05-09T18:13:25Z | |
dc.date.created | 2020-01-02T09:29:55Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Frigstad, Svein Oskar Høivik, Marte Lie Jahnsen, Jørgen Småstuen, Milada Cvancarova Grimstad, Tore Berset, Ingrid Prytz Huppertz-Hauss, Gert Hovde, Øistein Bernklev, Tomm Moum, Bjørn Jelsness-Jørgensen, Lars-Petter . Pain Severity and Vitamin D Deficiency in IBD Patients. Nutrients. 2019, 12(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/75307 | |
dc.description.abstract | Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain. This study aimed to determine whether there is an association between vitamin D deficiency and severity of pain in patients with IBD, and to investigate the influence of other socio-demographic and psychological variables on the experience of pain. Methods: Patients with IBD were recruited from nine hospitals in Norway in a multicenter cross-sectional study. The Brief Pain Inventory (BPI) questionnaire was used to measure pain. Disease activity was assessed using clinical disease activity indices, C-reactive protein (CRP) and fecal calprotectin. Regression models were fitted to explore a possible association between 25-hydroxyvitamin D and pain severity. Results: Of 407 patients included in the analyses, 229 (56%) had Crohn's disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency was present in half (203/407) of patients. Presence of pain was reported by 76% (309/407). More severe pain was associated with female gender and increased disease activity scores, but not with increased CRP or fecal calprotectin. In CD, patients without prior intra-abdominal surgery reported more severe pain. In multivariate analyses, there was no association between 25-hydroxyvitamin D and pain severity. Conclusions: In this study, no significant association between pain severity and vitamin D deficiency was revealed in patients with IBD. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Pain Severity and Vitamin D Deficiency in IBD Patients | |
dc.type | Journal article | |
dc.creator.author | Frigstad, Svein Oskar | |
dc.creator.author | Høivik, Marte Lie | |
dc.creator.author | Jahnsen, Jørgen | |
dc.creator.author | Småstuen, Milada Cvancarova | |
dc.creator.author | Grimstad, Tore | |
dc.creator.author | Berset, Ingrid Prytz | |
dc.creator.author | Huppertz-Hauss, Gert | |
dc.creator.author | Hovde, Øistein | |
dc.creator.author | Bernklev, Tomm | |
dc.creator.author | Moum, Bjørn | |
dc.creator.author | Jelsness-Jørgensen, Lars-Petter | |
cristin.unitcode | 185,53,11,13 | |
cristin.unitname | Gastromedisinsk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1764879 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrients&rft.volume=12&rft.spage=&rft.date=2019 | |
dc.identifier.jtitle | Nutrients | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.3390/nu12010026 | |
dc.identifier.urn | URN:NBN:no-78432 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2072-6643 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/75307/2/Pain%2BSeverity%2Band%2BVitamin%2BD%2BDeficiency%2Bin%2BIBD%2BPatients%2B.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 26 | |