dc.date.accessioned | 2020-05-08T18:54:52Z | |
dc.date.available | 2020-05-08T18:54:52Z | |
dc.date.created | 2019-12-19T12:10:00Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Do Vale Moreira, Nayla Cristina Montenegro, Renan Magalhaes Meyer, Haakon E Bhowmik, Bishwajit Mdala, Ibrahimu Siddiquee, Tasnima Fernandes, Virginia Oliveira Hussain, Akhtar . Glycated hemoglobin in the diagnosis of diabetes mellitus in a Semi-Urban Brazilian population. International Journal of Environmental Research and Public Health. 2019, 16(19) | |
dc.identifier.uri | http://hdl.handle.net/10852/75264 | |
dc.description.abstract | The study evaluated glycated hemoglobin (HbA1c) as a diagnostic tool for diabetes and pre-diabetes in the Brazilian population. Further, the homeostasis model assessment of insulin resistance (HOMA-IR) was also examined against HbA1c values to identify the most suitable cut-off points for HOMA-IR to predict the risk of diabetes. A cross-sectional study was conducted among 714 randomly selected subjects. HbA1c, fasting, and 2 h plasma glucose values were measured. Insulin resistance estimates were calculated with HOMA-IR. The receiver operating characteristic curve assessed HbA1c performance. The adjusted prevalence rate of diabetes mellitus was 14.7%, and pre-diabetes 14.2%. The optimal HbA1c cut-off value was ≥6.8% for the diagnosis of diabetes, and ≥6.0% for pre-diabetes. The area under the curve using HbA1c was 0.85 (95% CI: 0.80–0.90) for detecting diabetes and 0.61 (95% CI: 0.55–0.67) for pre-diabetes. The optimal HOMA-IR cut-off value was 2.06 for HbA1c at 6.8%. The HbA1c cut-off value of ≥6.8% may be suitable for diagnosing diabetes in the Brazilian population. Our results do not support the use of HbA1c to diagnose pre-diabetes. A HOMA-IR cut-off point of 2.06 was a sensitive marker to assess the risk of diabetes. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Glycated hemoglobin in the diagnosis of diabetes mellitus in a Semi-Urban Brazilian population | |
dc.type | Journal article | |
dc.creator.author | Do Vale Moreira, Nayla Cristina | |
dc.creator.author | Montenegro, Renan Magalhaes | |
dc.creator.author | Meyer, Haakon E | |
dc.creator.author | Bhowmik, Bishwajit | |
dc.creator.author | Mdala, Ibrahimu | |
dc.creator.author | Siddiquee, Tasnima | |
dc.creator.author | Fernandes, Virginia Oliveira | |
dc.creator.author | Hussain, Akhtar | |
cristin.unitcode | 185,52,14,0 | |
cristin.unitname | Avdeling for samfunnsmedisin og global helse | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1762928 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International Journal of Environmental Research and Public Health&rft.volume=16&rft.spage=&rft.date=2019 | |
dc.identifier.jtitle | International Journal of Environmental Research and Public Health | |
dc.identifier.volume | 16 | |
dc.identifier.issue | 19 | |
dc.identifier.doi | https://doi.org/10.3390/ijerph16193598 | |
dc.identifier.urn | URN:NBN:no-78379 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1660-4601 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/75264/2/do%2BVAle%2BMoreira%2Bet%2Bal.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 3598 | |