dc.date.accessioned | 2020-05-05T18:20:40Z | |
dc.date.available | 2020-12-18T23:46:13Z | |
dc.date.created | 2019-12-20T11:33:50Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Evjen, Sigvart Åstrand, Ove Alexander Høgmoen Gaarder, Mona Paulsen, Ragnhild Elisabeth Fiksdahl, Anne Knuutila, Hanna K . Degradative behavior and toxicity of alkylated imidazoles. Industrial & Engineering Chemistry Research. 2020 | |
dc.identifier.uri | http://hdl.handle.net/10852/75119 | |
dc.description.abstract | The thermal and oxidative degradation behavior and the corrosiveness of imidazole (Im), 2-methylimidazole (2MIm), 2-ethyl-4-methylimidazole (2E4MIm), 2,4,5-trimethylimidazole (2,4,5MIm), and 1,2,4,5-tetramethylimidazole (1,2,4,5MIm) were investigated in a CO2 rich environment. The imidazoles demonstrated high thermal stability in all solutions; however, Im and 2MIm were corrosive. Polyalkylated imidazoles were less stable toward oxidation compared to Im. Rat cell (PC-12) toxicology screening of Im and 45 alkylated imidazoles showed reduced toxicity for polyalkylated imidazoles compared to Im. Cell viability correlated negatively with cLogP predictions when cLogP > 3. The high rate of oxidative degradation and formation of potentially carcinogenic degradation products will prevent the use of polyalkylated imidazoles in industrial processes directed toward CO2. | en_US |
dc.language | EN | |
dc.title | Degradative behavior and toxicity of alkylated imidazoles | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Evjen, Sigvart | |
dc.creator.author | Åstrand, Ove Alexander Høgmoen | |
dc.creator.author | Gaarder, Mona | |
dc.creator.author | Paulsen, Ragnhild Elisabeth | |
dc.creator.author | Fiksdahl, Anne | |
dc.creator.author | Knuutila, Hanna K | |
cristin.unitcode | 185,15,23,20 | |
cristin.unitname | Seksjon for farmasøytisk kjemi | |
cristin.ispublished | false | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1763274 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Industrial & Engineering Chemistry Research&rft.volume=&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | Industrial & Engineering Chemistry Research | |
dc.identifier.volume | 59 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 587 | |
dc.identifier.endpage | 595 | |
dc.identifier.doi | https://doi.org/10.1021/acs.iecr.9b05100 | |
dc.identifier.urn | URN:NBN:no-78256 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0888-5885 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/75119/2/Manuscript%2Bdegradation%2B121219%2Brevised%2Bwith%2Bsupporting%2Binformation.pdf | |
dc.type.version | AcceptedVersion | |
dc.relation.project | NFR/233776 | |