Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
dc.date.accessioned | 2020-04-29T13:08:40Z | |
dc.date.available | 2020-04-29T13:08:40Z | |
dc.date.created | 2019-04-26T14:42:27Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Liu, Ming Jiang, Yu Wedow, Robbee Li, Yue Brazel, David M. Chen, Fang Datta, Gargi Davila-Velderrain, Jose Mitchell, Amy Skogholt, Anne Heidi Sivertsen, Børge Stordal, Eystein Morken, Gunnar Kallestad, Håvard Heuch, Ingrid Zwart, John-Anker Fjukstad, Katrine Kveli Pedersen, Linda Margareth Johnsen, Marianne Bakke Skrove, Marit Synnøve Indredavik, Marit Sæbø Drange, Ole Kristian Bjerkeset, Ottar Børte, Sigrid Stensland, Synne Choquet, Hélène Docherty, Anna R. Faul, Jessica D. Foerster, Johanna R. Fritsche, Lars Gabrielsen, Maiken Elvestad Gordon, Scott D. Haessler, Jeffrey Hottenga, Jouke-Jan Huang, Hongyan Jang, Seon-Kyeong Jansen, Philip R. Ling, Yueh Mägi, Reedik Matoba, Nana McMahon, George Mulas, Antonella Orrú, Valeria Palviainen, Teemu Pandit, Anita Reginsson, Gunnar W. Smith, Jennifer A. Taylor, Amy E. Turman, Constance Willemsen, Gonneke Young, Hannah Young, Kendra A. Zajac, Gregory J.M. Zhao, Wei Zhou, Wei Björnsdóttir, Gyda Thora Boardman, Jason D. Boehnke, Michael Boomsma, Dorret I. Chen, Chu Davies, Gareth E. Eaton, Charles B. Winsvold, Bendik K S Hveem, Kristian Vrieze, Scott . Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics. 2019, 51(2), 237-244 | |
dc.identifier.uri | http://hdl.handle.net/10852/74966 | |
dc.description.abstract | Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders. They are heritable and etiologically related behaviors that have been resistant to gene discovery efforts. In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association. Smoking phenotypes were positively genetically correlated with many health conditions, whereas alcohol use was negatively correlated with these conditions, such that increased genetic risk for alcohol use is associated with lower disease risk. We report evidence for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission. The results provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.title | Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Liu, Ming | |
dc.creator.author | Jiang, Yu | |
dc.creator.author | Wedow, Robbee | |
dc.creator.author | Li, Yue | |
dc.creator.author | Brazel, David M. | |
dc.creator.author | Chen, Fang | |
dc.creator.author | Datta, Gargi | |
dc.creator.author | Davila-Velderrain, Jose | |
dc.creator.author | Mitchell, Amy | |
dc.creator.author | Skogholt, Anne Heidi | |
dc.creator.author | Sivertsen, Børge | |
dc.creator.author | Stordal, Eystein | |
dc.creator.author | Morken, Gunnar | |
dc.creator.author | Kallestad, Håvard | |
dc.creator.author | Heuch, Ingrid | |
dc.creator.author | Zwart, John-Anker | |
dc.creator.author | Fjukstad, Katrine Kveli | |
dc.creator.author | Pedersen, Linda Margareth | |
dc.creator.author | Johnsen, Marianne Bakke | |
dc.creator.author | Skrove, Marit Synnøve | |
dc.creator.author | Indredavik, Marit Sæbø | |
dc.creator.author | Drange, Ole Kristian | |
dc.creator.author | Bjerkeset, Ottar | |
dc.creator.author | Børte, Sigrid | |
dc.creator.author | Stensland, Synne | |
dc.creator.author | Choquet, Hélène | |
dc.creator.author | Docherty, Anna R. | |
dc.creator.author | Faul, Jessica D. | |
dc.creator.author | Foerster, Johanna R. | |
dc.creator.author | Fritsche, Lars | |
dc.creator.author | Gabrielsen, Maiken Elvestad | |
dc.creator.author | Gordon, Scott D. | |
dc.creator.author | Haessler, Jeffrey | |
dc.creator.author | Hottenga, Jouke-Jan | |
dc.creator.author | Huang, Hongyan | |
dc.creator.author | Jang, Seon-Kyeong | |
dc.creator.author | Jansen, Philip R. | |
dc.creator.author | Ling, Yueh | |
dc.creator.author | Mägi, Reedik | |
dc.creator.author | Matoba, Nana | |
dc.creator.author | McMahon, George | |
dc.creator.author | Mulas, Antonella | |
dc.creator.author | Orrú, Valeria | |
dc.creator.author | Palviainen, Teemu | |
dc.creator.author | Pandit, Anita | |
dc.creator.author | Reginsson, Gunnar W. | |
dc.creator.author | Smith, Jennifer A. | |
dc.creator.author | Taylor, Amy E. | |
dc.creator.author | Turman, Constance | |
dc.creator.author | Willemsen, Gonneke | |
dc.creator.author | Young, Hannah | |
dc.creator.author | Young, Kendra A. | |
dc.creator.author | Zajac, Gregory J.M. | |
dc.creator.author | Zhao, Wei | |
dc.creator.author | Zhou, Wei | |
dc.creator.author | Björnsdóttir, Gyda Thora | |
dc.creator.author | Boardman, Jason D. | |
dc.creator.author | Boehnke, Michael | |
dc.creator.author | Boomsma, Dorret I. | |
dc.creator.author | Chen, Chu | |
dc.creator.author | Davies, Gareth E. | |
dc.creator.author | Eaton, Charles B. | |
dc.creator.author | Winsvold, Bendik K S | |
dc.creator.author | Hveem, Kristian | |
dc.creator.author | Vrieze, Scott | |
cristin.unitcode | 185,53,42,0 | |
cristin.unitname | Nevroklinikken | |
cristin.ispublished | true | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1694237 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Genetics&rft.volume=51&rft.spage=237&rft.date=2019 | |
dc.identifier.jtitle | Nature Genetics | |
dc.identifier.volume | 51 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 237 | |
dc.identifier.endpage | 244 | |
dc.identifier.doi | http://dx.doi.org/10.1038/s41588-018-0307-5 | |
dc.identifier.urn | URN:NBN:no-78031 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1061-4036 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/74966/1/Association%2Bstudies%2Bof%2Bup%2Bto%2B1.2%2Bmillion%2Bindividuals%2Byield%2Bnew%2Binsights%2Binto%2Bthe%2Bgenetic%2Betiology%2Bof%2Btobacco%2Band%2Balcohol%2Buse.pdf | |
dc.type.version | AcceptedVersion | |
dc.relation.project | SKGJ/SKGJ-MED-015 |
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