dc.date.accessioned | 2020-04-21T19:42:20Z | |
dc.date.available | 2020-04-21T19:42:20Z | |
dc.date.created | 2019-07-31T08:33:42Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Jacobsen, Daniel Pitz Eriksen, Mina Baarnes Rajalingam, Dhaksshaginy Nymoen, Ingeborg Nielsen, Morten Birkeland Einarsen, Ståle Gjerstad, Johannes . Exposure to workplace bullying, microRNAs and pain. Evidence of a moderating effect of miR-30c rs928508 and miR-223 rs3848900. Stress. 2019 | |
dc.identifier.uri | http://hdl.handle.net/10852/74726 | |
dc.description.abstract | Prolonged exposure to bullying behaviors may give rise to symptoms such as anxiety, depression and chronic pain. Earlier data suggest that these symptoms often are associated with stress-induced low-grade systemic inflammation. Here, using data from both animals and humans, we examined the moderating role of microRNAs (miRNAs, miRs) in this process. In the present study, a resident-intruder paradigm, blood samples, tissue harvesting and subsequent qPCR analyses were used to screen for stress-induced changes in circulating miRNAs in rats. The negative acts questionnaire (NAQ), TaqMan assays and a numeric rating scale (NRS) for pain intensity were then used to examine the associations among bullying behaviors, relevant miRNA polymorphisms and pain in a probability sample of 996 Norwegian employees. In rats, inhibited weight gain, reduced pituitary POMC expression, adrenal Nr3c1 mRNA downregulation, as well as increased miR-146a, miR-30c and miR-223 in plasma were observed following 1 week of repeated exposure to social stress. When following up the miRNA findings from the animal study in the human working population, a stronger relationship between NAQ and NRS scores was observed in subjects with the miR-30c GG genotype (rs928508) compared to other subjects. A stronger relationship between NAQ and NRS scores was also seen in men with the miR-223 G genotype (rs3848900) as compared to other men. Our findings show that social stress may induce many physiological changes including changed expression of miRNAs. We conclude that the miR-30c GG genotype in men and women, and the miR-223 G genotype in men, amplify the association between exposure to bullying behaviors and pain. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Exposure to workplace bullying, microRNAs and pain. Evidence of a moderating effect of miR-30c rs928508 and miR-223 rs3848900 | |
dc.type | Journal article | |
dc.creator.author | Jacobsen, Daniel Pitz | |
dc.creator.author | Eriksen, Mina Baarnes | |
dc.creator.author | Rajalingam, Dhaksshaginy | |
dc.creator.author | Nymoen, Ingeborg | |
dc.creator.author | Nielsen, Morten Birkeland | |
dc.creator.author | Einarsen, Ståle | |
dc.creator.author | Gjerstad, Johannes | |
cristin.unitcode | 185,15,29,0 | |
cristin.unitname | Institutt for biovitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1713351 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Stress&rft.volume=&rft.spage=&rft.date=2019 | |
dc.identifier.jtitle | Stress | |
dc.identifier.volume | 23 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 77 | |
dc.identifier.endpage | 86 | |
dc.identifier.doi | https://doi.org/10.1080/10253890.2019.1642320 | |
dc.identifier.urn | URN:NBN:no-77816 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1025-3890 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/74726/5/Exposure_to_workplace_bullying_article.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/250127 | |
dc.relation.project | NFR/237777 | |