dc.date.accessioned | 2020-04-06T18:22:30Z | |
dc.date.available | 2020-04-06T18:22:30Z | |
dc.date.created | 2019-06-06T14:37:51Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Johnsen, Guro Mørk Størvold, Gro Leite Alnæs-Katjavivi, Patji Roald, Borghild Golic, Michaela Dechend, Ralf Redman, Christopher W.G. Staff, Anne Cathrine . Lymphocyte characterization of decidua basalis spiral arteries with acute atherosis in preeclamptic and normotensive pregnancies. Journal of Reproductive Immunology. 2019, 132, 42-48 | |
dc.identifier.uri | http://hdl.handle.net/10852/74391 | |
dc.description.abstract | Uteroplacental acute atherosis (AA) is a common spiral arterial lesion in preeclampsia, characterized by intramural foam cells, fibrinoid necrosis, and a perivascular immune cell infiltrate. A clear definition of this infiltrate is lacking. Therefore, our aim was to characterize lymphocytes in pre-defined zones regarding spiral arteries with or without AA, from preeclamptic and normotensive pregnancies.
Lymphocytes were characterized in decidua basalis samples (n = 91), previously evaluated for AA, around spiral arteries in three pre-defined zones; 1) intramural, 2) perivascular and 3) interstitial. Adjacent serial sections were immunostained to identify different T-cell populations (CD3+, CD8+, FOXP3+), and NK-cells (CD56+). CD3+CD8- T-cells were also identified. These were presumed to be largely CD4+ T-cells.
AA was associated with significantly higher intramural CD3+ cell concentrations in Zone 1, in both normotensives and preeclamptics. In preeclamptics only, this difference extended into Zone 2. Similar results were observed for CD3+CD8- cells. AA was also associated with increased intramural CD8+ concentration; however, the number of cells was low. Regulatory T-cells (FOXP3+) were generally scarce or absent in all pre-defined zones. Although intramural NK-cells (CD56+) were scarce, the intramural concentration was significantly lower in spiral arteries with AA compared to without AA in preeclamptics.
Our main finding was that CD3+CD8-FoxP3- T-cells were associated with AA. We therefore suggest that T-cells, of a non-regulatory CD4+ subtype, could be involved in the formation of spiral artery AA in the decidua basalis. Whether AA gives rise to, or is partly mediated by increased T-cell concentration around the lesions, remains to be determined. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Lymphocyte characterization of decidua basalis spiral arteries with acute atherosis in preeclamptic and normotensive pregnancies | |
dc.type | Journal article | |
dc.creator.author | Johnsen, Guro Mørk | |
dc.creator.author | Størvold, Gro Leite | |
dc.creator.author | Alnæs-Katjavivi, Patji | |
dc.creator.author | Roald, Borghild | |
dc.creator.author | Golic, Michaela | |
dc.creator.author | Dechend, Ralf | |
dc.creator.author | Redman, Christopher W.G. | |
dc.creator.author | Staff, Anne Cathrine | |
cristin.unitcode | 185,53,45,10 | |
cristin.unitname | Obstetrikk og gynekologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1703217 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Reproductive Immunology&rft.volume=132&rft.spage=42&rft.date=2019 | |
dc.identifier.jtitle | Journal of Reproductive Immunology | |
dc.identifier.volume | 132 | |
dc.identifier.startpage | 42 | |
dc.identifier.endpage | 48 | |
dc.identifier.doi | https://doi.org/10.1016/j.jri.2019.03.003 | |
dc.identifier.urn | URN:NBN:no-77503 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0165-0378 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/74391/4/1-s2.0-S0165037818303450-main.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | HSØ/2,014,026 | |
dc.relation.project | NFR/230,652 | |