dc.date.accessioned | 2020-04-02T18:12:14Z | |
dc.date.available | 2020-04-02T18:12:14Z | |
dc.date.created | 2019-09-22T13:54:48Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Kjeldsen-Kragh, Jens Titze, Thomas Larsen Lie, Benedicte Alexandra Vaage, John T. Kjær, Mette . HLA-DRB3*01:01 exhibits a dose-dependent impact on HPA-1a antibody levels in HPA-1a-immunized women. Blood Advances. 2019, 3(7), 945-951 | |
dc.identifier.uri | http://hdl.handle.net/10852/74351 | |
dc.description.abstract | HLA-DRB3*01:01 is a predisposing factor for human platelet antigen 1a (HPA-1a) immunization, which is responsible for most cases of fetal and neonatal alloimmune thrombocytopenia. The aim of this study was to investigate if the HLA-DRB3*01:01 allele imposes a dose-dependent effect on anti-HPA-1a levels and neonatal platelet counts. One hundred and thirty HPA-1a–immunized women were divided into 3 groups: HLA-DRB3*01:01 negative, HLA-DRB3*01:01 hemizygous or heterozygous, and HLA-DRB3*01:01 homozygous. The dose of the HLA-DRB3*01:01 allele was determined by sequencing exon 2 of the HLA-DRB3 gene followed by HLA-DRB3 and HLA-DRB1 typing of selected samples. Anti-HPA-1a levels at time of delivery and neonatal platelet counts were compared among groups. There was a significant dose-dependent effect of the HLA-DRB3*01:01 allele on anti-HPA-1a levels (global P value [Pglobal] = .0032). Median (range) anti-HPA-1a levels were 1.5 IU/mL (0.0-19.0 IU/mL), 21.1 IU/mL (0.0-1967 IU/mL), and 43.7 IU/mL (1.0-980 IU/mL) in women with 0, 1, and 2 copies of the HLA-DRB3*01:01 allele, respectively. There was also a significant, but opposite, dose-dependent effect of the mother’s HLA-DRB3*01:01 allele on the platelet count of the newborn (Pglobal = .0155). Median (range) neonatal platelet counts were 241 × 109/L (59 × 109/L to 393 × 109/L), 107 × 109/L (4 × 109/L to 387 × 109/L) and 32 × 109/L (4 × 109/L to 352 × 109/L) for newborns of mothers with 0, 1, and 2 copies of the HLA-DRB3*01:01 allele, respectively. Thus, the HLA-DRB3*01:01 allele exhibits a dose-dependent impact on maternal anti-HPA-1a levels in HPA-1a–immunized women. | |
dc.language | EN | |
dc.publisher | American Society of Hematology | |
dc.title | HLA-DRB3*01:01 exhibits a dose-dependent impact on HPA-1a antibody levels in HPA-1a-immunized women | |
dc.type | Journal article | |
dc.creator.author | Kjeldsen-Kragh, Jens | |
dc.creator.author | Titze, Thomas Larsen | |
dc.creator.author | Lie, Benedicte Alexandra | |
dc.creator.author | Vaage, John T. | |
dc.creator.author | Kjær, Mette | |
cristin.unitcode | 185,53,18,12 | |
cristin.unitname | Avdeling for immunologi og transfusjonsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1727555 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Blood Advances&rft.volume=3&rft.spage=945&rft.date=2019 | |
dc.identifier.jtitle | Blood Advances | |
dc.identifier.volume | 3 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 945 | |
dc.identifier.endpage | 951 | |
dc.identifier.doi | https://doi.org/10.1182/bloodadvances.2019032227 | |
dc.identifier.urn | URN:NBN:no-77460 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2473-9529 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/74351/1/John%2BT%2BVaage%2B2019-HLA-DRB30101%2Bexhibits%2Ba%2Bdose%2Bdependent%2Bimpact%2Bon%2BHPA%2B1a%2Bantibodylevels%2Bin%2BHPA-1a%2Bimmunized%2Bwomen.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | EC/FP7/305986 | |