dc.date.accessioned | 2020-03-26T19:22:27Z | |
dc.date.available | 2020-03-26T19:22:27Z | |
dc.date.created | 2019-09-03T16:33:46Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Hokstad, Ingrid Deyab, Gia Fagerland, Morten Lyberg, Torstein Hjeltnes, Gunnbjørg Førre, Øystein Thorleiv Agewall, Stefan Mollnes, Tom Eirik Hollan, Ivana . Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study. PLOS ONE. 2019, 14(7), 1-16 | |
dc.identifier.uri | http://hdl.handle.net/10852/74231 | |
dc.description.abstract | Background The complement system is involved in pathogenesis of cardiovascular disease, and might play a role in accelerated atherogenesis in spondylarthropathies (SpA). Hence, we examined complement activation in SpA, and its relationship to antirheumatic treatment, inflammatory and cardiovascular markers. Methods From PSARA, a prospective observational study, we examined 51 SpA patients (31 psoriatic arthritis (PsA), and 20 ankylosing spondylitis (AS)), starting tumor necrosis factor (TNF) inhibitor alone (n = 25), combined with methotrexate (MTX) (n = 10), or MTX monotherapy (n = 16). Complement activation was determined by the soluble terminal complement complex (sC5b-9), inflammation by erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), and endothelial function by finger plethysmography (Endopat) at baseline, after 6 weeks and 6 months of treatment. Results SpA patients had sC5b-9 levels at (PsA) or above (AS) the upper limit of the estimated reference range. Median sC5b-9 levels decreased significantly from baseline to 6 weeks, with no significant difference between the AS and PsA group. Notably, a significant reduction in sC5b-9 was observed after administration of TNF inhibitor ± MTX, whereas no significant changes were observed in patients treated with MTX alone. Between 6 weeks and 6 months, sC5b-9 remained stable across all subgroups. Reduction in sC5b-9 was independently related to decreased ESR and CRP, and to increased high density cholesterol and total cholesterol. Reduction in sC5b-9 from baseline to 6 weeks was associated with improved EF in age and gender adjusted analyses. Conclusion TNF-inhibition, but not MTX monotherapy, led to rapid and sustained reduction of complement activation in SpA. Thus, the observed decrease in cardiovascular morbidity in patients treated with TNF-inhibitors might be partly due to its beneficial effect on complement. Trial registration Clinical Trials (NCT00902005), retrospectively registered on the 14th of May 2009. | |
dc.description.abstract | Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study | |
dc.language | EN | |
dc.publisher | PLOS | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study | |
dc.type | Journal article | |
dc.creator.author | Hokstad, Ingrid | |
dc.creator.author | Deyab, Gia | |
dc.creator.author | Fagerland, Morten | |
dc.creator.author | Lyberg, Torstein | |
dc.creator.author | Hjeltnes, Gunnbjørg | |
dc.creator.author | Førre, Øystein Thorleiv | |
dc.creator.author | Agewall, Stefan | |
dc.creator.author | Mollnes, Tom Eirik | |
dc.creator.author | Hollan, Ivana | |
cristin.unitcode | 185,53,11,21 | |
cristin.unitname | Avdeling for klinisk service | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1721155 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLOS ONE&rft.volume=14&rft.spage=1&rft.date=2019 | |
dc.identifier.jtitle | PLOS ONE | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 7 | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0220079 | |
dc.identifier.urn | URN:NBN:no-77331 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-6203 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/74231/2/Hokstad%2Bet%2Bal.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e0220079 | |
dc.relation.project | NFR/223255 | |