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Identification of nine new susceptibility loci for endometrial cancer

dc.date.accessioned2020-02-04T20:57:31Z
dc.date.available2020-02-04T20:57:31Z
dc.date.created2018-09-21T10:57:00Z
dc.date.issued2018
dc.identifier.citationO'Mara, Tracy A. Glubb, Dylan M. Amant, Frédéric Annibali, Daniela Ashton, Katie Attia, John Auer, Paul L. Beckmann, Matthias W. Black, Amanda Bolla, Manjeet K. Brauch, Hiltrud Brenner, Hermann Brinton, Louise Buchanan, Daniel D. Burwinkel, Barbara Chang-Claude, Jenny Chanock, Stephen J. Chen, Chu Chen, Maxine M. Cheng, Timothy H.T. Clarke, Christine L. Clendenning, Mark Cook, Linda S. Couch, Fergus J. Cox, Angela Crous-Bous, Marta Czene, Kamila Day, Felix Dennis, Joe Depreeuw, Jeroen Doherty, Jennifer Anne Dörk, Thilo Dowdy, Sean C. Dürst, Matthias Ekici, Arif B. Fasching, Peter A. Fridley, Brooke L. Friedenreich, Christine M. Fritschi, Lin Fung, Jenny García-Closas, Montserrat Gaudet, Mia M. Giles, Graham G. Goode, Ellen L. Gorman, Maggie Haiman, Christopher A. Hall, Per Hankison, Susan E. Healey, Catherine S. Hein, Alexander Hillemanns, Peter Hodgson, Shirley Høivik, Erling Andre Holliday, Elizabeth G. Hopper, John L. Hunter, David J. Jones, Angela Krakstad, Camilla Kristensen, Vessela N. Lambrechts, Diether Marchand, Loic Le Liang, Xiaolin Lindblom, Annika Lissowska, Jolanta Long, Jirong Lu, Lingeng Magliocco, Anthony M. Martin, Lynn McEvoy, Mark Meindl, Alfons Michailidou, Kyriaki Milne, Roger L. Mints, Miriam Montgomery, Grant W. Nassir, Rami Olsson, Håkan Orlow, Irene Otton, Geoffrey Palles, Claire Perry, John R.B. Peto, Julian Pooler, Loreall Prescott, Jennifer Proietto, Tony Rebbeck, Timothy R. Risch, Harvey A. Rogers, Peter A.W. Rübner, Matthias Runnebaum, Ingo Sacerdote, Carlotta Sarto, Gloria E. Schumacher, Fredrick Scott, Rodney J. Setiawan, V. Wendy Shah, Mitul Sheng, Xin Shu, Xiao-Ou Southey, Melissa C. Swerdlow, Anthony J. Tham, Emma Trovik, Jone Turman, Constance Tyrer, Jonathan P. Vachon, Celine VanDen Berg, David Vanderstichele, Adriaan Wang, Zhaoming Webb, Penelope M. Wentzensen, Nicolas Werner, Henrica Maria Johanna Winham, Stacey J. Wolk, Alicja Xia, Lucy Xiang, Yong-Bing Yang, Hannah P. Yu, Herbert Zheng, Wei Pharoah, Paul D.P. Dunning, Alison M. Kraft, Peter De Vivo, Immaculata Tomlinson, Ian Easton, Douglas F. Spurdle, Amanda B. Thompson, Deborah J. . Identification of nine new susceptibility loci for endometrial cancer. Nature Communications. 2018, 9:3166, 1-12
dc.identifier.urihttp://hdl.handle.net/10852/72758
dc.description.abstractEndometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.en_US
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleIdentification of nine new susceptibility loci for endometrial canceren_US
dc.typeJournal articleen_US
dc.creator.authorO'Mara, Tracy A.
dc.creator.authorGlubb, Dylan M.
dc.creator.authorAmant, Frédéric
dc.creator.authorAnnibali, Daniela
dc.creator.authorAshton, Katie
dc.creator.authorAttia, John
dc.creator.authorAuer, Paul L.
dc.creator.authorBeckmann, Matthias W.
dc.creator.authorBlack, Amanda
dc.creator.authorBolla, Manjeet K.
dc.creator.authorBrauch, Hiltrud
dc.creator.authorBrenner, Hermann
dc.creator.authorBrinton, Louise
dc.creator.authorBuchanan, Daniel D.
dc.creator.authorBurwinkel, Barbara
dc.creator.authorChang-Claude, Jenny
dc.creator.authorChanock, Stephen J.
dc.creator.authorChen, Chu
dc.creator.authorChen, Maxine M.
dc.creator.authorCheng, Timothy H.T.
dc.creator.authorClarke, Christine L.
dc.creator.authorClendenning, Mark
dc.creator.authorCook, Linda S.
dc.creator.authorCouch, Fergus J.
dc.creator.authorCox, Angela
dc.creator.authorCrous-Bous, Marta
dc.creator.authorCzene, Kamila
dc.creator.authorDay, Felix
dc.creator.authorDennis, Joe
dc.creator.authorDepreeuw, Jeroen
dc.creator.authorDoherty, Jennifer Anne
dc.creator.authorDörk, Thilo
dc.creator.authorDowdy, Sean C.
dc.creator.authorDürst, Matthias
dc.creator.authorEkici, Arif B.
dc.creator.authorFasching, Peter A.
dc.creator.authorFridley, Brooke L.
dc.creator.authorFriedenreich, Christine M.
dc.creator.authorFritschi, Lin
dc.creator.authorFung, Jenny
dc.creator.authorGarcía-Closas, Montserrat
dc.creator.authorGaudet, Mia M.
dc.creator.authorGiles, Graham G.
dc.creator.authorGoode, Ellen L.
dc.creator.authorGorman, Maggie
dc.creator.authorHaiman, Christopher A.
dc.creator.authorHall, Per
dc.creator.authorHankison, Susan E.
dc.creator.authorHealey, Catherine S.
dc.creator.authorHein, Alexander
dc.creator.authorHillemanns, Peter
dc.creator.authorHodgson, Shirley
dc.creator.authorHøivik, Erling Andre
dc.creator.authorHolliday, Elizabeth G.
dc.creator.authorHopper, John L.
dc.creator.authorHunter, David J.
dc.creator.authorJones, Angela
dc.creator.authorKrakstad, Camilla
dc.creator.authorKristensen, Vessela N.
dc.creator.authorLambrechts, Diether
dc.creator.authorMarchand, Loic Le
dc.creator.authorLiang, Xiaolin
dc.creator.authorLindblom, Annika
dc.creator.authorLissowska, Jolanta
dc.creator.authorLong, Jirong
dc.creator.authorLu, Lingeng
dc.creator.authorMagliocco, Anthony M.
dc.creator.authorMartin, Lynn
dc.creator.authorMcEvoy, Mark
dc.creator.authorMeindl, Alfons
dc.creator.authorMichailidou, Kyriaki
dc.creator.authorMilne, Roger L.
dc.creator.authorMints, Miriam
dc.creator.authorMontgomery, Grant W.
dc.creator.authorNassir, Rami
dc.creator.authorOlsson, Håkan
dc.creator.authorOrlow, Irene
dc.creator.authorOtton, Geoffrey
dc.creator.authorPalles, Claire
dc.creator.authorPerry, John R.B.
dc.creator.authorPeto, Julian
dc.creator.authorPooler, Loreall
dc.creator.authorPrescott, Jennifer
dc.creator.authorProietto, Tony
dc.creator.authorRebbeck, Timothy R.
dc.creator.authorRisch, Harvey A.
dc.creator.authorRogers, Peter A.W.
dc.creator.authorRübner, Matthias
dc.creator.authorRunnebaum, Ingo
dc.creator.authorSacerdote, Carlotta
dc.creator.authorSarto, Gloria E.
dc.creator.authorSchumacher, Fredrick
dc.creator.authorScott, Rodney J.
dc.creator.authorSetiawan, V. Wendy
dc.creator.authorShah, Mitul
dc.creator.authorSheng, Xin
dc.creator.authorShu, Xiao-Ou
dc.creator.authorSouthey, Melissa C.
dc.creator.authorSwerdlow, Anthony J.
dc.creator.authorTham, Emma
dc.creator.authorTrovik, Jone
dc.creator.authorTurman, Constance
dc.creator.authorTyrer, Jonathan P.
dc.creator.authorVachon, Celine
dc.creator.authorVanDen Berg, David
dc.creator.authorVanderstichele, Adriaan
dc.creator.authorWang, Zhaoming
dc.creator.authorWebb, Penelope M.
dc.creator.authorWentzensen, Nicolas
dc.creator.authorWerner, Henrica Maria Johanna
dc.creator.authorWinham, Stacey J.
dc.creator.authorWolk, Alicja
dc.creator.authorXia, Lucy
dc.creator.authorXiang, Yong-Bing
dc.creator.authorYang, Hannah P.
dc.creator.authorYu, Herbert
dc.creator.authorZheng, Wei
dc.creator.authorPharoah, Paul D.P.
dc.creator.authorDunning, Alison M.
dc.creator.authorKraft, Peter
dc.creator.authorDe Vivo, Immaculata
dc.creator.authorTomlinson, Ian
dc.creator.authorEaston, Douglas F.
dc.creator.authorSpurdle, Amanda B.
dc.creator.authorThompson, Deborah J.
cristin.unitcode185,53,82,10
cristin.unitnameAvdeling for klinisk molekylærbiologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1611959
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=9:3166&rft.spage=1&rft.date=2018
dc.identifier.jtitleNature Communications
dc.identifier.volume9
dc.identifier.issue1
dc.identifier.doihttps://doi.org/10.1038/s41467-018-05427-7
dc.identifier.urnURN:NBN:no-75842
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2041-1723
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/72758/1/s41467-018-05427-7.pdf
dc.type.versionPublishedVersion
cristin.articleid3166


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