Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
dc.date.accessioned | 2020-02-04T20:15:13Z | |
dc.date.available | 2020-02-04T20:15:13Z | |
dc.date.created | 2018-12-21T09:22:40Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Demontis, Ditte Walters, Raymond K. Martin, Joanna Mattheisen, Manuel Als, Thomas D. Agerbo, Esben Baldursson, Gisli Belliveau, Rich Bybjerg-Grauholm, Jonas Bækvad-Hansen, Marie Cerrato, Felecia Chambert, Kimberly Churchhouse, Claire Dumont, Ashley Gandal, Michael Goldstein, Jacqueline I. Grasby, Katrina L. Grove, Jakob Gudmundsson, Ólafur O. Hansen, Christine S Hauberg, Mads Engel Hollegaard, Mads V Howrigan, Daniel P. Huang, Hailiang Jugessur, Astanand Myhre, Ronny Stoltenberg, Camilla Andreassen, Ole Andreas Asherson, Philip Burton, Christie L. Boomsma, Dorret I. Cormand, Bru Dalsgaard, Søren Haavik, Jan Sonuga-Barke, Edmund J.S. Sullivan, Patrick F. Thapar, Anita Tung, Joyce Y. Waldman, Irwin Medland, Sarah E. Stefansson, Kari Nordentoft, Merete Hougaard, David M. Werge, Thomas Mors, Ole Mortensen, Preben Bo Daly, Mark J. Faraone, Stephen V. Børglum, Anders D. Neale, Benjamin M . Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics. 2018, 51, 63-75 | |
dc.identifier.uri | http://hdl.handle.net/10852/72742 | |
dc.description.abstract | Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits. | |
dc.language | EN | |
dc.title | Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder | |
dc.type | Journal article | |
dc.creator.author | Demontis, Ditte | |
dc.creator.author | Walters, Raymond K. | |
dc.creator.author | Martin, Joanna | |
dc.creator.author | Mattheisen, Manuel | |
dc.creator.author | Als, Thomas D. | |
dc.creator.author | Agerbo, Esben | |
dc.creator.author | Baldursson, Gisli | |
dc.creator.author | Belliveau, Rich | |
dc.creator.author | Bybjerg-Grauholm, Jonas | |
dc.creator.author | Bækvad-Hansen, Marie | |
dc.creator.author | Cerrato, Felecia | |
dc.creator.author | Chambert, Kimberly | |
dc.creator.author | Churchhouse, Claire | |
dc.creator.author | Dumont, Ashley | |
dc.creator.author | Gandal, Michael | |
dc.creator.author | Goldstein, Jacqueline I. | |
dc.creator.author | Grasby, Katrina L. | |
dc.creator.author | Grove, Jakob | |
dc.creator.author | Gudmundsson, Ólafur O. | |
dc.creator.author | Hansen, Christine S | |
dc.creator.author | Hauberg, Mads Engel | |
dc.creator.author | Hollegaard, Mads V | |
dc.creator.author | Howrigan, Daniel P. | |
dc.creator.author | Huang, Hailiang | |
dc.creator.author | Jugessur, Astanand | |
dc.creator.author | Myhre, Ronny | |
dc.creator.author | Stoltenberg, Camilla | |
dc.creator.author | Andreassen, Ole Andreas | |
dc.creator.author | Asherson, Philip | |
dc.creator.author | Burton, Christie L. | |
dc.creator.author | Boomsma, Dorret I. | |
dc.creator.author | Cormand, Bru | |
dc.creator.author | Dalsgaard, Søren | |
dc.creator.author | Haavik, Jan | |
dc.creator.author | Sonuga-Barke, Edmund J.S. | |
dc.creator.author | Sullivan, Patrick F. | |
dc.creator.author | Thapar, Anita | |
dc.creator.author | Tung, Joyce Y. | |
dc.creator.author | Waldman, Irwin | |
dc.creator.author | Medland, Sarah E. | |
dc.creator.author | Stefansson, Kari | |
dc.creator.author | Nordentoft, Merete | |
dc.creator.author | Hougaard, David M. | |
dc.creator.author | Werge, Thomas | |
dc.creator.author | Mors, Ole | |
dc.creator.author | Mortensen, Preben Bo | |
dc.creator.author | Daly, Mark J. | |
dc.creator.author | Faraone, Stephen V. | |
dc.creator.author | Børglum, Anders D. | |
dc.creator.author | Neale, Benjamin M | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | preprint | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1646548 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Genetics&rft.volume=51&rft.spage=63&rft.date=2018 | |
dc.identifier.jtitle | Nature Genetics | |
dc.identifier.volume | 51 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 63 | |
dc.identifier.endpage | 75 | |
dc.identifier.doi | https://doi.org/10.1038/s41588-018-0269-7 | |
dc.identifier.urn | URN:NBN:no-75863 | |
dc.type.document | Tidsskriftartikkel | |
dc.source.issn | 1061-4036 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/72742/1/1646548%2BMain_text_ADHD_GWAS_submitted_revised_PP.pdf | |
dc.type.version | SubmittedVersion | |
dc.relation.project | NFR/262700 |
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