dc.date.accessioned | 2020-01-15T19:46:36Z | |
dc.date.available | 2020-01-15T19:46:36Z | |
dc.date.created | 2018-10-16T15:44:11Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Kim, Kun-Yong Tanaka, Yoshiaki Su, Juan Cakir, Bilal Xiang, Yangfei Patterson, Benjamin Ding, Junjun Jung, Yong-Wook Kim, Ji-Hyun Hysolli, Eriona Lee, Haelim Dajani, Rana Kim, Jonghwan Zhong, Mei Lee, Jeong-Heon Skalnik, David Lim, Jeong Mook Sullivan, Gareth Wang, Jianlong Park, In-Hyun . Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a. Nature Communications. 2018, 9:2583, 1-13 | |
dc.identifier.uri | http://hdl.handle.net/10852/72217 | |
dc.description.abstract | Embryonic stem cells (ESCs) maintain pluripotency through unique epigenetic states. When ESCs commit to a specific lineage, epigenetic changes in histones and DNA accompany the transition to specialized cell types. Investigating how epigenetic regulation controls lineage specification is critical in order to generate the required cell types for clinical applications. Uhrf1 is a widely known hemi-methylated DNA-binding protein, playing a role in DNA methylation through the recruitment of Dnmt1 and in heterochromatin formation alongside G9a, Trim28, and HDACs. Although Uhrf1 is not essential in ESC self-renewal, it remains elusive how Uhrf1 regulates cell specification. Here we report that Uhrf1 forms a complex with the active trithorax group, the Setd1a/COMPASS complex, to maintain bivalent histone marks, particularly those associated with neuroectoderm and mesoderm specification. Overall, our data demonstrate that Uhrf1 safeguards proper differentiation via bivalent histone modifications. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a | |
dc.type | Journal article | |
dc.creator.author | Kim, Kun-Yong | |
dc.creator.author | Tanaka, Yoshiaki | |
dc.creator.author | Su, Juan | |
dc.creator.author | Cakir, Bilal | |
dc.creator.author | Xiang, Yangfei | |
dc.creator.author | Patterson, Benjamin | |
dc.creator.author | Ding, Junjun | |
dc.creator.author | Jung, Yong-Wook | |
dc.creator.author | Kim, Ji-Hyun | |
dc.creator.author | Hysolli, Eriona | |
dc.creator.author | Lee, Haelim | |
dc.creator.author | Dajani, Rana | |
dc.creator.author | Kim, Jonghwan | |
dc.creator.author | Zhong, Mei | |
dc.creator.author | Lee, Jeong-Heon | |
dc.creator.author | Skalnik, David | |
dc.creator.author | Lim, Jeong Mook | |
dc.creator.author | Sullivan, Gareth | |
dc.creator.author | Wang, Jianlong | |
dc.creator.author | Park, In-Hyun | |
cristin.unitcode | 185,51,20,10 | |
cristin.unitname | SFF - Hybrid Technology Hub | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1620860 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=9:2583&rft.spage=1&rft.date=2018 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 9 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-018-04818-0 | |
dc.identifier.urn | URN:NBN:no-75334 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/72217/2/s41467-018-04818-0.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 2583 | |