dc.date.accessioned | 2020-01-15T19:02:34Z | |
dc.date.available | 2020-01-15T19:02:34Z | |
dc.date.created | 2018-07-02T13:17:19Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Kalheim, Lisa Flem Fladby, Tormod Coello, Christopher Bjørnerud, Atle Selnes, Per . [18F]-Flutemetamol Uptake in Cortex and White Matter: Comparison with Cerebrospinal Fluid Biomarkers and [18F]-Fludeoxyglucose. Journal of Alzheimer's Disease. 2018, 62(4), 1595-1607 | |
dc.identifier.uri | http://hdl.handle.net/10852/72194 | |
dc.description.abstract | Flutemetamol (18F-Flut) is an [18F]-labelled amyloid PET tracer with increasing availability. The main objectives of this study were to investigate 1) cerebrospinal fluid (CSF) Aβ 1-42 (Aβ42) concentrations associated with regional 18F-Flut uptake, 2) associations between cortical 18F-Flut and [18F]-fludeoxyglucose (18F-FDG)-PET, and 3) the potential use of 18F-Flut in WM pathology. Cognitively impaired, nondemented subjects were recruited (n = 44). CSF was drawn, and 18F-Flut-PET, 18F-FDG-PET, and MRI performed. Our main findings were: 1) Different Alzheimer’s disease predilection areas showed increased 18F-Flut retention at different CSF Aβ42 concentrations (posterior regions were involved at higher concentrations). 2) There were strong negative correlations between regional cortical 18F-Flut and 18F-FDG uptake. 3) Increased 18F-Flut uptake were observed in multiple subcortical regions in amyloid positive subjects, including investigated reference regions. However, WM hyperintensity 18F-Flut standardized uptake value ratios (SUVr) were not significantly different, thus we cannot definitely conclude that the higher uptake in 18F-Flut(+) is due to amyloid deposition. In conclusion, our findings support clinical use of CSF Aβ42, putatively relate decreasing CSF Aβ42 concentrations to a sequence of regional amyloid deposition, and associate amyloid pathology to cortical hypometabolism. However, we cannot conclude that 18F-Flut-PET is a suitable marker for WM pathology due to high aberrant WM uptake. | |
dc.language | EN | |
dc.publisher | IOS Press | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | [18F]-Flutemetamol Uptake in Cortex and White Matter: Comparison with Cerebrospinal Fluid Biomarkers and [18F]-Fludeoxyglucose | |
dc.type | Journal article | |
dc.creator.author | Kalheim, Lisa Flem | |
dc.creator.author | Fladby, Tormod | |
dc.creator.author | Coello, Christopher | |
dc.creator.author | Bjørnerud, Atle | |
dc.creator.author | Selnes, Per | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og laboratoriefag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1595188 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Alzheimer's Disease&rft.volume=62&rft.spage=1595&rft.date=2018 | |
dc.identifier.jtitle | Journal of Alzheimer's Disease | |
dc.identifier.volume | 62 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 1595 | |
dc.identifier.endpage | 1607 | |
dc.identifier.doi | https://doi.org/10.3233/JAD-170582 | |
dc.identifier.urn | URN:NBN:no-75324 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1387-2877 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/72194/1/jad170582.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/269774 | |