dc.date.accessioned | 2020-01-12T19:07:33Z | |
dc.date.available | 2020-01-12T19:07:33Z | |
dc.date.created | 2019-01-04T13:39:44Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Witoelar, Aree Rongve, Arvid Almdahl, Ina Selseth Ulstein, Ingun Engvig, Andreas White, Linda Rosemary Selbæk, Geir Stordal, Eystein Andersen, Fredrik Brækhus, Anne Saltvedt, Ingvild Engedal, Knut Hughes, Timothy Bergh, Sverre Bråthen, Geir Bogdanovic, Nenad Bettella, Francesco Wang, Yunpeng Athanasiu, Lavinia Bahrami, Shahram Le Hellard, Stephanie Giddaluru, Sudheer Dale, Anders M Sando, Sigrid Botne Steinberg, Stacy Stefansson, Hreinn Snaedal, Jon Desikan, Rahul S Stefansson, Kari Aarsland, Dag Djurovic, Srdjan Fladby, Tormod Andreassen, Ole Andreas . Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports. 2018 | |
dc.identifier.uri | http://hdl.handle.net/10852/72134 | |
dc.description.abstract | A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) of AD cases and controls of European descent from the multi-center DemGene network across Norway and two independent European cohorts. In a two-stage process, we first performed a meta-analysis using GWAS results from 2,893 AD cases and 6,858 cognitively normal controls from Norway and 25,580 cases and 48,466 controls from the International Genomics of Alzheimer’s Project (IGAP), denoted the discovery sample. Second, we selected the top hits (p < 1 × 10−6) from the discovery analysis for replication in an Icelandic cohort consisting of 5,341 cases and 110,008 controls. We identified a novel genomic region with genome-wide significant association with AD on chromosome 4 (combined analysis OR = 1.07, p = 2.48 x 10-8). This finding implicated HS3ST1, a gene expressed throughout the brain particularly in the cerebellar cortex. In addition, we identified IGHV1-68 in the discovery sample, previously not associated with AD. We also associated USP6NL/ECHDC3 and BZRAP1-AS1 to AD, confirming findings from a follow-up transethnic study. These new gene loci provide further evidence for AD as a polygenic disorder, and suggest new mechanistic pathways that warrant further investigation. | en_US |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Witoelar, Aree | |
dc.creator.author | Rongve, Arvid | |
dc.creator.author | Almdahl, Ina Selseth | |
dc.creator.author | Ulstein, Ingun | |
dc.creator.author | Engvig, Andreas | |
dc.creator.author | White, Linda Rosemary | |
dc.creator.author | Selbæk, Geir | |
dc.creator.author | Stordal, Eystein | |
dc.creator.author | Andersen, Fredrik | |
dc.creator.author | Brækhus, Anne | |
dc.creator.author | Saltvedt, Ingvild | |
dc.creator.author | Engedal, Knut | |
dc.creator.author | Hughes, Timothy | |
dc.creator.author | Bergh, Sverre | |
dc.creator.author | Bråthen, Geir | |
dc.creator.author | Bogdanovic, Nenad | |
dc.creator.author | Bettella, Francesco | |
dc.creator.author | Wang, Yunpeng | |
dc.creator.author | Athanasiu, Lavinia | |
dc.creator.author | Bahrami, Shahram | |
dc.creator.author | Le Hellard, Stephanie | |
dc.creator.author | Giddaluru, Sudheer | |
dc.creator.author | Dale, Anders M | |
dc.creator.author | Sando, Sigrid Botne | |
dc.creator.author | Steinberg, Stacy | |
dc.creator.author | Stefansson, Hreinn | |
dc.creator.author | Snaedal, Jon | |
dc.creator.author | Desikan, Rahul S | |
dc.creator.author | Stefansson, Kari | |
dc.creator.author | Aarsland, Dag | |
dc.creator.author | Djurovic, Srdjan | |
dc.creator.author | Fladby, Tormod | |
dc.creator.author | Andreassen, Ole Andreas | |
cristin.unitcode | 185,51,12,58 | |
cristin.unitname | Gruppe for Neural Computation | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1650460 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=&rft.spage=&rft.date=2018 | |
dc.identifier.jtitle | Scientific Reports | |
dc.identifier.pagecount | 8 | |
dc.identifier.doi | https://doi.org/10.1038/s41598-018-36429-6 | |
dc.identifier.urn | URN:NBN:no-75257 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2045-2322 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/72134/2/Witoelar%2Bet%2Bal.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 18088 | |
dc.relation.project | NFR/251134 | |