dc.date.accessioned | 2020-01-06T21:06:09Z | |
dc.date.available | 2020-01-06T21:06:09Z | |
dc.date.created | 2018-07-25T14:07:02Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Sundlisæter, Nina Beate Paulshus Aga, Anna-Birgitte Inge Christoffer, Olsen Hammer, Hilde Berner Uhlig, Till Heijde, Desirée van der Kvien, Tore Kristian Lillegraven, Siri Haavardsholm, Espen A. . Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: Associations to future good radiographic and physical outcomes. Annals of the Rheumatic Diseases. 2018, 77(10), 1421-1425 | |
dc.identifier.uri | http://hdl.handle.net/10852/71926 | |
dc.description.abstract | Objective: To explore associations between remission, based on clinical and ultrasound definitions, and future good radiographic and physical outcome in early rheumatoid arthritis (RA).
Methods: Newly diagnosed patients with RA followed a treat-to-target strategy incorporating ultrasound information in the Aiming for Remission in rheumatoid arthritis: a randomised trial examining the benefit of ultrasound in a Clinical TIght Control regimen (ARCTIC) trial. We defined 6-month remission according to Disease Activity Score, Disease Activity Score in 28 joints-erythrocyte sedimentation rate, American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean criteria, Simplified Disease Activity Index, Clinical Disease Activity Index and two ultrasound definitions (no power Doppler signal, grey scale score ≤2). Two outcomes were defined: no radiographic progression and good outcome (no radiographic progression+physical function≥general population median), both sustained 12–24 months. We calculated the ORs of these outcomes for the remission definitions.
Results: Of 103 patients, 42%–82% reached remission at 6 months, dependent on definition. Seventy-one per cent of patients had no radiographic progression and 37% had good outcome. An association between 6-month remission and no radiographic progression was observed for ACR/EULAR Boolean remission (44 joints, OR 3.2, 95% CI 1.2 to 8.4), ultrasound power Doppler (OR 3.6, 95% CI 1.3 to 10.0) and grey scale remission (OR 3.2, 95% CI 1.2 to 8.0). All clinical, but not ultrasound remission criteria were associated with achievement of a good outcome.
Conclusions: Our data support ACR/EULAR Boolean remission based on 44 joints as the preferred treatment target in early RA. Absence of ultrasound inflammation was associated with no radiographic progression. | |
dc.language | EN | |
dc.publisher | HighWire Press | |
dc.title | Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: Associations to future good radiographic and physical outcomes | |
dc.type | Journal article | |
dc.creator.author | Sundlisæter, Nina Beate Paulshus | |
dc.creator.author | Aga, Anna-Birgitte | |
dc.creator.author | Inge Christoffer, Olsen | |
dc.creator.author | Hammer, Hilde Berner | |
dc.creator.author | Uhlig, Till | |
dc.creator.author | Heijde, Desirée van der | |
dc.creator.author | Kvien, Tore Kristian | |
dc.creator.author | Lillegraven, Siri | |
dc.creator.author | Haavardsholm, Espen A. | |
cristin.unitcode | 185,53,48,13 | |
cristin.unitname | Avdeling for revmatologi, hud- og infeksjonssykdommer | |
cristin.ispublished | true | |
cristin.fulltext | preprint | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1598633 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Annals of the Rheumatic Diseases&rft.volume=77&rft.spage=1421&rft.date=2018 | |
dc.identifier.jtitle | Annals of the Rheumatic Diseases | |
dc.identifier.volume | 77 | |
dc.identifier.issue | 10 | |
dc.identifier.startpage | 1421 | |
dc.identifier.endpage | 1425 | |
dc.identifier.doi | https://doi.org/10.1136/annrheumdis-2017-212830 | |
dc.identifier.urn | URN:NBN:no-75010 | |
dc.type.document | Tidsskriftartikkel | |
dc.source.issn | 0003-4967 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/71926/1/1598633_ARD_2019.pdf | |
dc.type.version | SubmittedVersion | |