dc.date.accessioned | 2019-12-13T19:25:57Z | |
dc.date.available | 2019-12-13T19:25:57Z | |
dc.date.created | 2018-11-22T19:52:47Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Heuser, Kjell Nome, Cecilie Pettersen, Klas Åbjørsbråten, Knut Sindre Jensen, Vidar Tang, Wannan Sprengel, Rolf Taubøll, Erik Nagelhus, Erlend Arnulf Enger, Rune . Ca2+ signals in astrocytes facilitate spread of epileptiform activity. Cerebral Cortex. 2018, 28(11), 4036-4048 | |
dc.identifier.uri | http://hdl.handle.net/10852/71621 | |
dc.description.abstract | Epileptic seizures are associated with increased astrocytic Ca2+ signaling, but the fine spatiotemporal kinetics of the ictal astrocyte–neuron interplay remains elusive. By using 2-photon imaging of awake head-fixed mice with chronic hippocampal windows we demonstrate that astrocytic Ca2+ signals precede neuronal Ca2+ elevations during the initial bout of kainate-induced seizures. On average, astrocytic Ca2+ elevations preceded neuronal activity in CA1 by about 8 s. In subsequent bouts of epileptic seizures, astrocytes and neurons were activated simultaneously. The initial astrocytic Ca2+ elevation was abolished in mice lacking the type 2 inositol-1,4,5-trisphosphate-receptor (Itpr2−/−). Furthermore, we found that Itpr2−/− mice exhibited 60% less epileptiform activity compared with wild-type mice when assessed by telemetric EEG monitoring. In both genotypes we also demonstrate that spreading depression waves may play a part in seizure termination. Our findings imply a role for astrocytic Ca2+ signals in ictogenesis. | |
dc.language | EN | |
dc.publisher | Oxford University Press | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Ca2+ signals in astrocytes facilitate spread of epileptiform activity | |
dc.type | Journal article | |
dc.creator.author | Heuser, Kjell | |
dc.creator.author | Nome, Cecilie | |
dc.creator.author | Pettersen, Klas | |
dc.creator.author | Åbjørsbråten, Knut Sindre | |
dc.creator.author | Jensen, Vidar | |
dc.creator.author | Tang, Wannan | |
dc.creator.author | Sprengel, Rolf | |
dc.creator.author | Taubøll, Erik | |
dc.creator.author | Nagelhus, Erlend Arnulf | |
dc.creator.author | Enger, Rune | |
cristin.unitcode | 185,53,42,13 | |
cristin.unitname | Nevrologisk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1634008 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral Cortex&rft.volume=28&rft.spage=4036&rft.date=2018 | |
dc.identifier.jtitle | Cerebral Cortex | |
dc.identifier.volume | 28 | |
dc.identifier.issue | 11 | |
dc.identifier.startpage | 4036 | |
dc.identifier.endpage | 4048 | |
dc.identifier.doi | https://doi.org/10.1093/cercor/bhy196 | |
dc.identifier.urn | URN:NBN:no-74729 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1047-3211 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/71621/1/Heuser%252C%2B2018%252C%2BCa%2Bog%2Bastrocytter.pdf | |
dc.type.version | PublishedVersion | |