dc.date.accessioned | 2019-12-11T20:07:00Z | |
dc.date.available | 2019-12-11T20:07:00Z | |
dc.date.created | 2018-09-16T20:05:57Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Zusinaite, Eva Ianevski, Alexandr Niukkanen, Diana Poranen, Minna M. Bjørås, Magnar Afset, Jan Egil Tenson, Tanel Velagapudi, Vidya Merits, Andres Kainov, Denis . A systems approach to study immuno- and neuro-modulatory properties of antiviral agents. Viruses. 2018, 10:423(8), 1-13 | |
dc.identifier.uri | http://hdl.handle.net/10852/71586 | |
dc.description.abstract | There are dozens of approved, investigational and experimental antiviral agents. Many of these agents cause serious side effects, which can only be revealed after drug administration. Identification of the side effects prior to drug administration is challenging. Here we describe an ex vivo approach for studying immuno- and neuro-modulatory properties of antiviral agents, which may be associated with potential side effects of these therapeutics. The current approach combines drug toxicity/efficacy tests and transcriptomics, which is followed by mRNA, cytokine and metabolite profiling. We demonstrated the utility of this approach with several examples of antiviral agents. We also showed that the approach can utilize different immune stimuli and cell types. It can also include other omics techniques, such as genomics and epigenomics, to allow identification of individual markers associated with adverse reactions to antivirals with immuno- and neuro-modulatory properties. | |
dc.language | EN | |
dc.publisher | MDPI AG | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | A systems approach to study immuno- and neuro-modulatory properties of antiviral agents | |
dc.type | Journal article | |
dc.creator.author | Zusinaite, Eva | |
dc.creator.author | Ianevski, Alexandr | |
dc.creator.author | Niukkanen, Diana | |
dc.creator.author | Poranen, Minna M. | |
dc.creator.author | Bjørås, Magnar | |
dc.creator.author | Afset, Jan Egil | |
dc.creator.author | Tenson, Tanel | |
dc.creator.author | Velagapudi, Vidya | |
dc.creator.author | Merits, Andres | |
dc.creator.author | Kainov, Denis | |
cristin.unitcode | 185,53,18,11 | |
cristin.unitname | Avdeling for mikrobiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1609880 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Viruses&rft.volume=10:423&rft.spage=1&rft.date=2018 | |
dc.identifier.jtitle | Viruses | |
dc.identifier.volume | 10 | |
dc.identifier.issue | 8 | |
dc.identifier.doi | https://doi.org/10.3390/v10080423 | |
dc.identifier.urn | URN:NBN:no-74678 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1999-4915 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/71586/1/Zisinaite_Viruses-10-00423_Cristin-post%2B1609880.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 423 | |