dc.date.accessioned | 2019-12-11T19:16:30Z | |
dc.date.available | 2019-12-11T19:16:30Z | |
dc.date.created | 2018-11-11T12:04:25Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Shabestari, Maziar Kise, Nina Jullum Landin, Maria Augusta Dos S Silva Sessing, Sølve Hellund, Johan Castberg Reseland, Janne Elin Eriksen, Erik Fink Haugen, Ida Kristin . Enhanced angiogenesis and increased bone turnover characterize bone marrow lesions in osteoarthritis at the base of the thumb. Bone and Joint Research. 2018, 7(6), 406-413 | |
dc.identifier.uri | http://hdl.handle.net/10852/71564 | |
dc.description.abstract | Objectives
Little is known about tissue changes underlying bone marrow lesions (BMLs) in non-weight-bearing joints with osteoarthritis (OA). Our aim was to characterize BMLs in OA of the hand using dynamic histomorphometry. We therefore quantified bone turnover and angiogenesis in subchondral bone at the base of the thumb, and compared the findings with control bone from hip OA.
Methods
Patients with OA at the base of the thumb, or the hip, underwent preoperative MRI to assess BMLs, and tetracycline labelling to determine bone turnover. Three groups were compared: trapezium bones removed by trapeziectomy from patients with thumb base OA (n = 20); femoral heads with (n = 24); and those without (n = 9) BMLs obtained from patients with hip OA who underwent total hip arthroplasty.
Results
All trapezium bones demonstrated MRI-defined BMLs. Compared with femoral heads without BMLs, the trapezia demonstrated significantly higher bone turnover (mean sd 0.2 (0.1) versus 0.01 (0.01) µm3/µm2/day), mineralizing surface (18.5% (13.1) versus 1.4% (1.3)) and vascularity (5.2% (1.1) versus 1.2% (0.6)). Femoral heads with BMLs exhibited higher bone turnover (0.3 (0.2) versus 0.2 (0.1) µm3/µm2/day), a higher mineralization rate (26.6% (10.6) versus 18.6% (11.9)) and greater trabecular thickness (301.3 µm (108) versus 163.6 µm (24.8)) than the trapezia.
Conclusion
Bone turnover and angiogenesis were enhanced in BMLs of both the thumb base and hip OA, of which the latter exhibited the highest bone turnover. Thus, the increase in bone turnover in weight-bearing joints like the hip may be more pronounced than less mechanically loaded osteoarthritic joints demonstrating BMLs. The histological changes observed may explain the water signal from BMLs on MRI. | |
dc.language | EN | |
dc.publisher | The British Editorial Society of Bone & Joint Surgery | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Enhanced angiogenesis and increased bone turnover characterize bone marrow lesions in osteoarthritis at the base of the thumb | |
dc.type | Journal article | |
dc.creator.author | Shabestari, Maziar | |
dc.creator.author | Kise, Nina Jullum | |
dc.creator.author | Landin, Maria Augusta Dos S Silva | |
dc.creator.author | Sessing, Sølve | |
dc.creator.author | Hellund, Johan Castberg | |
dc.creator.author | Reseland, Janne Elin | |
dc.creator.author | Eriksen, Erik Fink | |
dc.creator.author | Haugen, Ida Kristin | |
cristin.unitcode | 185,16,17,62 | |
cristin.unitname | Biomaterialer | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1629069 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bone and Joint Research&rft.volume=7&rft.spage=406&rft.date=2018 | |
dc.identifier.jtitle | Bone and Joint Research | |
dc.identifier.volume | 7 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 406 | |
dc.identifier.endpage | 413 | |
dc.identifier.doi | https://doi.org/10.1302/2046-3758.76.BJR-2017-0083.R3 | |
dc.identifier.urn | URN:NBN:no-74697 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2046-3758 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/71564/2/Shabestari%2Bet%2Bal.pdf | |
dc.type.version | PublishedVersion | |