dc.date.accessioned | 2019-12-09T19:13:38Z | |
dc.date.available | 2019-12-09T19:13:38Z | |
dc.date.created | 2019-01-08T09:38:10Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Fassnacht, Christina Tocchini, Cristina Kumari, Pooja Gaidatzis, Dimos Stadler, Michael B Ciosk, Rafal . The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.. PLoS Genetics. 2018 | |
dc.identifier.uri | http://hdl.handle.net/10852/71445 | |
dc.description.abstract | Endogenous RNAi (endoRNAi) is a conserved mechanism for fine-tuning gene expression. In the nematode Caenorhabditis elegans, several endoRNAi pathways are required for the successful development of reproductive cells. The CSR-1 endoRNAi pathway promotes germ cell development, primarily by facilitating the expression of germline genes. In this study, we report a novel function for the CSR-1 pathway in preventing premature activation of embryonic transcription in the developing oocytes, which is accompanied by a general Pol II activation. This CSR-1 function requires its RNase activity, suggesting that, by controlling the levels of maternal mRNAs, CSR-1-dependent endoRNAi contributes to an orderly reprogramming of transcription during the oocyte-to-embryo transition. | en_US |
dc.language | EN | |
dc.publisher | Public Library of Science (PLoS) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans. | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Fassnacht, Christina | |
dc.creator.author | Tocchini, Cristina | |
dc.creator.author | Kumari, Pooja | |
dc.creator.author | Gaidatzis, Dimos | |
dc.creator.author | Stadler, Michael B | |
dc.creator.author | Ciosk, Rafal | |
cristin.unitcode | 185,15,29,40 | |
cristin.unitname | Seksjon for biokjemi og molekylærbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1652001 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS Genetics&rft.volume=&rft.spage=&rft.date=2018 | |
dc.identifier.jtitle | PLoS Genetics | |
dc.identifier.doi | https://doi.org/10.1371/journal.pgen.1007252 | |
dc.identifier.urn | URN:NBN:no-74577 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1553-7390 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/71445/1/The%2BCSR-1%2Bendogenous%2BRNAi%2Bpathway-journal.pgen.1007252.pdf | |
dc.type.version | PublishedVersion | |