dc.date.accessioned | 2019-11-20T19:15:01Z | |
dc.date.available | 2019-12-14T23:46:22Z | |
dc.date.created | 2018-11-15T12:31:11Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Hovde, Karoline Gianatti, Michele Witter, Menno Whitlock, Jonathan . Architecture and Organization of Mouse Posterior Parietal Cortex Relative to Extrastriate Areas. European Journal of Neuroscience. 2018 | |
dc.identifier.uri | http://hdl.handle.net/10852/70903 | |
dc.description.abstract | The posterior parietal cortex (PPC) is a multifaceted region of cortex, contributing to several cognitive processes including sensorimotor integration and spatial navigation. Although recent years have seen a considerable rise in the use of rodents, particularly mice, to investigate PPC and related networks, a coherent anatomical definition of PPC in the mouse is still lacking. To address this, we delineated the mouse PPC using cyto- and chemoarchitectural markers from Nissl-, parvalbumin- and muscarinic acetylcholine receptor M2-staining. Additionally, we performed bilateral triple anterograde tracer injections in primary visual cortex (V1) and prepared flattened tangential sections from one hemisphere and coronal sections from the other, allowing us to coregister the cytoarchitectural features of PPC with V1 projections. This revealed that extrastriate area A was largely contained within lateral PPC, that medial PPC overlapped with the anterior portion of area AM, and that anterior RL overlapped partially with area PtP. Furthermore, triple anterograde tracer injections in PPC showed strong projections to associative thalamic nuclei as well as higher visual areas, orbitofrontal, cingulate and secondary motor cortices. Retrograde circuit mapping with rabies virus further showed that all cortical connections were reciprocal. These combined approaches provide a coherent definition of mouse PPC that incorporates laminar architecture, extrastriate projections, thalamic, and cortico-cortical connections. | |
dc.description.abstract | Architecture and Organization of Mouse Posterior Parietal Cortex Relative to Extrastriate Areas | |
dc.language | EN | |
dc.title | Architecture and Organization of Mouse Posterior Parietal Cortex Relative to Extrastriate Areas | |
dc.title.alternative | ENEngelskEnglishArchitecture and Organization of Mouse Posterior Parietal Cortex Relative to Extrastriate Areas | |
dc.type | Journal article | |
dc.creator.author | Hovde, Karoline | |
dc.creator.author | Gianatti, Michele | |
dc.creator.author | Witter, Menno | |
dc.creator.author | Whitlock, Jonathan | |
cristin.unitcode | 185,51,12,58 | |
cristin.unitname | Gruppe for Neural Computation | |
cristin.ispublished | false | |
cristin.fulltext | postprint | |
cristin.fulltext | preprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1630943 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Journal of Neuroscience&rft.volume=&rft.spage=&rft.date=2018 | |
dc.identifier.jtitle | European Journal of Neuroscience | |
dc.identifier.volume | 49 | |
dc.identifier.issue | 10 | |
dc.identifier.startpage | 1313 | |
dc.identifier.endpage | 1329 | |
dc.identifier.doi | https://doi.org/10.1111/ejn.14280 | |
dc.identifier.urn | URN:NBN:no-74017 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0953-816X | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/70903/1/HGWW_EJN_Combined_Post-Print.pdf | |
dc.type.version | AcceptedVersion | |
dc.relation.project | NFR/239963 | |
dc.relation.project | EC/FP7/335328, RAT MIRROR CELL | |