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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

dc.date.accessioned2019-08-07T05:34:14Z
dc.date.available2019-08-07T05:34:14Z
dc.date.created2018-06-21T17:31:01Z
dc.date.issued2018
dc.identifier.citationDavies, Gail Lam, Max Harris, Sarah E. Trampush, Joey W. Luciano, Michelle Hill, W. David Hagenaars, Saskia P. Ritchie, Stuart J. Marioni, Riccardo E. Fawns-Ritchie, Chloe Liewald, David C.M. Okely, Judith A. Ahola-Olli, Ari V. Barnes, Catriona L.K. Bertram, Lars Bis, Joshua C. Burdick, Katherine E. Christoforou, Andrea Derosse, Pamela Djurovic, Srdjan Espeseth, Thomas Giakoumaki, Stella Giddaluru, Sudheer Gustavson, Daniel E. Hayward, Caroline Hofer, Edith Ikram, M. Arfan Karlsson, Robert Knowles, Emma Lahti, Jari Leber, Markus Li, Shuo Mather, Karen A. Melle, Ingrid Morris, Derek Oldmeadow, Christopher Palviainen, Teemu Payton, Antony Pazoki, Raha Petrovic, Katja Reynolds, Chandra A. Sargurupremraj, Muralidharan Scholz, Markus Smith, Jennifer A. Smith, Albert V. Terzikhan, Natalie Thalamuthu, Anbupalam Trompet, Stella van der Lee, Sven J. Ware, Erin B. Windham, B. Gwen Wright, Margaret J. Yang, Jingyun Yu, Jin Ames, David Amin, Najaf Amouyel, Philippe Andreassen, Ole Andreas Armstrong, Nicola J. Assareh, Amelia A Attia, John R. Attix, Deborah Avramopoulos, Dimitrios Bennett, David A. Böhmer, Anne C. Boyle, Patricia A. Brodaty, Henry Campbell, Harry Cannon, Tyrone D. Cirulli, Elizabeth T. Congdon, Eliza Conley, Emily Drabant Corley, Janie Cox, Simon R. Dale, Anders Dehghan, Abbas Dick, Danielle Dickinson, Dwight Eriksson, Johan G. Evangelou, Evangelos Faul, Jessica D. Ford, Ian Freimer, Nelson A. Gao, He Giegling, Ina Gillespie, Nathan A. Gordon, Scott D. Gottesman, Rebecca F. Griswold, Michael E. Gudnason, Vilmundur Harris, Tamara B. Hartmann, Annette M. Hatzimanolis, Alex Heiss, Gerardo Holliday, Elizabeth G. Joshi, Peter K. Kähönen, Mika Kardia, Sharon L.R. Karlsson, Ida Kleineidam, Luca Knopman, David S. Kochan, Nicole A. Konte, Bettina Kwok, John B. Le Hellard, Stephanie Lee, Teresa Lehtimäki, Terho Li, Shu-Chen Liu, Tian Koini, Marisa London, Edythe Longstreth, Will T. Lopez, Oscar L. Loukola, Anu Luck, Tobias Lundervold, Astri Lundquist, Anders Lyytikäinen, Leo-Pekka Martin, Nicholas G. Montgomery, Grant W. Murray, Alison D. Need, Anna C. Noordam, Raymond Nyberg, Lars Ollier, William Papenberg, Göran Pattie, Alison Polasek, Ozren Poldrack, Russell A. Psaty, Bruce M. Reppermund, Simone Riedel-Heller, Steffi G. Rose, Richard J. Rotter, Jerome I. Roussos, Panos Rovio, Suvi P. Saba, Yasaman Sabb, Fred W. Sachdev, Perminder S. Satizabal, Claudia L. Schmid, Matthias Scott, Rodney J. Scult, Matthew A. Simino, Jeannette Slagboom, P. Eline Smyrnis, Nikolaos Soumaré, Aïcha Stefanis, Nikos C. Stott, David J. Straub, Richard E. Sundet, Kjetil Søren Taylor, Adele M. Taylor, Kent D. Tzoulaki, Ioanna Tzourio, Christophe Uitterlinden, André Vitart, Veronique Voineskos, Aristotle N. Kaprio, Jaakko Wagner, Michael Wagner, Holger Weinhold, Leonie Wen, K. Hoyan Widén, Elisabeth Yang, Qiong Zhao, Wei Adams, Hieab H.H. Arking, Dan E. Bilder, Robert M. Bitsios, Panos Boerwinkle, Eric Chiba-Falek, Ornit Corvin, Aiden De Jager, Philip L. Debette, Stéphanie Donohoe, Gary Elliott, Paul Fitzpatrick, Annette L. Gill, Michael Glahn, David C. Hägg, Sara Hansell, Narelle K. Hariri, Ahmad Ikram, M. Kamran Jukema, J. Wouter Vuoksimaa, Eero Keller, Matthew C. Kremen, William S. Launer, Lenore Lindenberger, Ulman Palotie, Aarno Pedersen, Nancy L. Pendleton, Neil Porteous, David J. Räikkönen, Katri Raitakari, Olli T. Ramirez, Alfredo Reinvang, Ivar Rudan, Igor Rujescu, Dan Schmidt, Reinhold Schmidt, Helena Schofield, Peter W. Schofield, Peter R. Starr, John M. Steen, Vidar Martin Trollor, Julian N. Turner, Steven T. Van Duijn, Cornelia M. Villringer, Arno Weinberger, Daniel R. Weir, David R. Wilson, James F. Malhotra, Anil McIntosh, Andrew M. Gale, Catharine R. Seshadri, Sudha Mosley, Thomas H. Bressler, Jan Lencz, Todd Deary, Ian J. . Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. 2018, 9:2098, 1-16
dc.identifier.urihttp://hdl.handle.net/10852/69002
dc.description.abstractGeneral cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleStudy of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
dc.typeJournal article
dc.creator.authorDavies, Gail
dc.creator.authorLam, Max
dc.creator.authorHarris, Sarah E.
dc.creator.authorTrampush, Joey W.
dc.creator.authorLuciano, Michelle
dc.creator.authorHill, W. David
dc.creator.authorHagenaars, Saskia P.
dc.creator.authorRitchie, Stuart J.
dc.creator.authorMarioni, Riccardo E.
dc.creator.authorFawns-Ritchie, Chloe
dc.creator.authorLiewald, David C.M.
dc.creator.authorOkely, Judith A.
dc.creator.authorAhola-Olli, Ari V.
dc.creator.authorBarnes, Catriona L.K.
dc.creator.authorBertram, Lars
dc.creator.authorBis, Joshua C.
dc.creator.authorBurdick, Katherine E.
dc.creator.authorChristoforou, Andrea
dc.creator.authorDerosse, Pamela
dc.creator.authorDjurovic, Srdjan
dc.creator.authorEspeseth, Thomas
dc.creator.authorGiakoumaki, Stella
dc.creator.authorGiddaluru, Sudheer
dc.creator.authorGustavson, Daniel E.
dc.creator.authorHayward, Caroline
dc.creator.authorHofer, Edith
dc.creator.authorIkram, M. Arfan
dc.creator.authorKarlsson, Robert
dc.creator.authorKnowles, Emma
dc.creator.authorLahti, Jari
dc.creator.authorLeber, Markus
dc.creator.authorLi, Shuo
dc.creator.authorMather, Karen A.
dc.creator.authorMelle, Ingrid
dc.creator.authorMorris, Derek
dc.creator.authorOldmeadow, Christopher
dc.creator.authorPalviainen, Teemu
dc.creator.authorPayton, Antony
dc.creator.authorPazoki, Raha
dc.creator.authorPetrovic, Katja
dc.creator.authorReynolds, Chandra A.
dc.creator.authorSargurupremraj, Muralidharan
dc.creator.authorScholz, Markus
dc.creator.authorSmith, Jennifer A.
dc.creator.authorSmith, Albert V.
dc.creator.authorTerzikhan, Natalie
dc.creator.authorThalamuthu, Anbupalam
dc.creator.authorTrompet, Stella
dc.creator.authorvan der Lee, Sven J.
dc.creator.authorWare, Erin B.
dc.creator.authorWindham, B. Gwen
dc.creator.authorWright, Margaret J.
dc.creator.authorYang, Jingyun
dc.creator.authorYu, Jin
dc.creator.authorAmes, David
dc.creator.authorAmin, Najaf
dc.creator.authorAmouyel, Philippe
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorArmstrong, Nicola J.
dc.creator.authorAssareh, Amelia A
dc.creator.authorAttia, John R.
dc.creator.authorAttix, Deborah
dc.creator.authorAvramopoulos, Dimitrios
dc.creator.authorBennett, David A.
dc.creator.authorBöhmer, Anne C.
dc.creator.authorBoyle, Patricia A.
dc.creator.authorBrodaty, Henry
dc.creator.authorCampbell, Harry
dc.creator.authorCannon, Tyrone D.
dc.creator.authorCirulli, Elizabeth T.
dc.creator.authorCongdon, Eliza
dc.creator.authorConley, Emily Drabant
dc.creator.authorCorley, Janie
dc.creator.authorCox, Simon R.
dc.creator.authorDale, Anders
dc.creator.authorDehghan, Abbas
dc.creator.authorDick, Danielle
dc.creator.authorDickinson, Dwight
dc.creator.authorEriksson, Johan G.
dc.creator.authorEvangelou, Evangelos
dc.creator.authorFaul, Jessica D.
dc.creator.authorFord, Ian
dc.creator.authorFreimer, Nelson A.
dc.creator.authorGao, He
dc.creator.authorGiegling, Ina
dc.creator.authorGillespie, Nathan A.
dc.creator.authorGordon, Scott D.
dc.creator.authorGottesman, Rebecca F.
dc.creator.authorGriswold, Michael E.
dc.creator.authorGudnason, Vilmundur
dc.creator.authorHarris, Tamara B.
dc.creator.authorHartmann, Annette M.
dc.creator.authorHatzimanolis, Alex
dc.creator.authorHeiss, Gerardo
dc.creator.authorHolliday, Elizabeth G.
dc.creator.authorJoshi, Peter K.
dc.creator.authorKähönen, Mika
dc.creator.authorKardia, Sharon L.R.
dc.creator.authorKarlsson, Ida
dc.creator.authorKleineidam, Luca
dc.creator.authorKnopman, David S.
dc.creator.authorKochan, Nicole A.
dc.creator.authorKonte, Bettina
dc.creator.authorKwok, John B.
dc.creator.authorLe Hellard, Stephanie
dc.creator.authorLee, Teresa
dc.creator.authorLehtimäki, Terho
dc.creator.authorLi, Shu-Chen
dc.creator.authorLiu, Tian
dc.creator.authorKoini, Marisa
dc.creator.authorLondon, Edythe
dc.creator.authorLongstreth, Will T.
dc.creator.authorLopez, Oscar L.
dc.creator.authorLoukola, Anu
dc.creator.authorLuck, Tobias
dc.creator.authorLundervold, Astri
dc.creator.authorLundquist, Anders
dc.creator.authorLyytikäinen, Leo-Pekka
dc.creator.authorMartin, Nicholas G.
dc.creator.authorMontgomery, Grant W.
dc.creator.authorMurray, Alison D.
dc.creator.authorNeed, Anna C.
dc.creator.authorNoordam, Raymond
dc.creator.authorNyberg, Lars
dc.creator.authorOllier, William
dc.creator.authorPapenberg, Göran
dc.creator.authorPattie, Alison
dc.creator.authorPolasek, Ozren
dc.creator.authorPoldrack, Russell A.
dc.creator.authorPsaty, Bruce M.
dc.creator.authorReppermund, Simone
dc.creator.authorRiedel-Heller, Steffi G.
dc.creator.authorRose, Richard J.
dc.creator.authorRotter, Jerome I.
dc.creator.authorRoussos, Panos
dc.creator.authorRovio, Suvi P.
dc.creator.authorSaba, Yasaman
dc.creator.authorSabb, Fred W.
dc.creator.authorSachdev, Perminder S.
dc.creator.authorSatizabal, Claudia L.
dc.creator.authorSchmid, Matthias
dc.creator.authorScott, Rodney J.
dc.creator.authorScult, Matthew A.
dc.creator.authorSimino, Jeannette
dc.creator.authorSlagboom, P. Eline
dc.creator.authorSmyrnis, Nikolaos
dc.creator.authorSoumaré, Aïcha
dc.creator.authorStefanis, Nikos C.
dc.creator.authorStott, David J.
dc.creator.authorStraub, Richard E.
dc.creator.authorSundet, Kjetil Søren
dc.creator.authorTaylor, Adele M.
dc.creator.authorTaylor, Kent D.
dc.creator.authorTzoulaki, Ioanna
dc.creator.authorTzourio, Christophe
dc.creator.authorUitterlinden, André
dc.creator.authorVitart, Veronique
dc.creator.authorVoineskos, Aristotle N.
dc.creator.authorKaprio, Jaakko
dc.creator.authorWagner, Michael
dc.creator.authorWagner, Holger
dc.creator.authorWeinhold, Leonie
dc.creator.authorWen, K. Hoyan
dc.creator.authorWidén, Elisabeth
dc.creator.authorYang, Qiong
dc.creator.authorZhao, Wei
dc.creator.authorAdams, Hieab H.H.
dc.creator.authorArking, Dan E.
dc.creator.authorBilder, Robert M.
dc.creator.authorBitsios, Panos
dc.creator.authorBoerwinkle, Eric
dc.creator.authorChiba-Falek, Ornit
dc.creator.authorCorvin, Aiden
dc.creator.authorDe Jager, Philip L.
dc.creator.authorDebette, Stéphanie
dc.creator.authorDonohoe, Gary
dc.creator.authorElliott, Paul
dc.creator.authorFitzpatrick, Annette L.
dc.creator.authorGill, Michael
dc.creator.authorGlahn, David C.
dc.creator.authorHägg, Sara
dc.creator.authorHansell, Narelle K.
dc.creator.authorHariri, Ahmad
dc.creator.authorIkram, M. Kamran
dc.creator.authorJukema, J. Wouter
dc.creator.authorVuoksimaa, Eero
dc.creator.authorKeller, Matthew C.
dc.creator.authorKremen, William S.
dc.creator.authorLauner, Lenore
dc.creator.authorLindenberger, Ulman
dc.creator.authorPalotie, Aarno
dc.creator.authorPedersen, Nancy L.
dc.creator.authorPendleton, Neil
dc.creator.authorPorteous, David J.
dc.creator.authorRäikkönen, Katri
dc.creator.authorRaitakari, Olli T.
dc.creator.authorRamirez, Alfredo
dc.creator.authorReinvang, Ivar
dc.creator.authorRudan, Igor
dc.creator.authorRujescu, Dan
dc.creator.authorSchmidt, Reinhold
dc.creator.authorSchmidt, Helena
dc.creator.authorSchofield, Peter W.
dc.creator.authorSchofield, Peter R.
dc.creator.authorStarr, John M.
dc.creator.authorSteen, Vidar Martin
dc.creator.authorTrollor, Julian N.
dc.creator.authorTurner, Steven T.
dc.creator.authorVan Duijn, Cornelia M.
dc.creator.authorVillringer, Arno
dc.creator.authorWeinberger, Daniel R.
dc.creator.authorWeir, David R.
dc.creator.authorWilson, James F.
dc.creator.authorMalhotra, Anil
dc.creator.authorMcIntosh, Andrew M.
dc.creator.authorGale, Catharine R.
dc.creator.authorSeshadri, Sudha
dc.creator.authorMosley, Thomas H.
dc.creator.authorBressler, Jan
dc.creator.authorLencz, Todd
dc.creator.authorDeary, Ian J.
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1593018
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=9:2098&rft.spage=1&rft.date=2018
dc.identifier.jtitleNature Communications
dc.identifier.volume9:2098
dc.identifier.startpage1
dc.identifier.endpage16
dc.identifier.doihttp://dx.doi.org/10.1038/s41467-018-04362-x
dc.identifier.urnURN:NBN:no-72144
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2041-1723
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/69002/1/Study%2Bof%2B300%252C486%2Bindividuals%2Bidentifies%2B148%2Bindependent%2Bgenetic%2Bloci%2Binfluencing%2Bgeneral%2Bcognitive%2Bfunction.pdf
dc.type.versionPublishedVersion
dc.relation.projectNFR/223273
dc.relation.projectSKGJ/SKGJ-MED-008


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