dc.date.accessioned | 2019-06-21T05:26:18Z | |
dc.date.available | 2019-06-21T05:26:18Z | |
dc.date.created | 2019-04-08T13:18:43Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Sun, Yi-Qian Burgess, Stephen Staley, James R. Wood, Angela M. Bell, Steven Kaptoge, Stephen Guo, Qi Bolton, Thomas R. Mason, Amy M Butterworth, Adam S. Di Angelantonio, Emanuele Vie, Gunnhild Åberge Bjørngaard, Johan Håkon Kinge, Jonas Minet Chen, Yue Mai, Xiao-Mei . Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses. BMJ-BRITISH MEDICAL JOURNAL. 2019, 364 | |
dc.identifier.uri | http://hdl.handle.net/10852/68459 | |
dc.description.abstract | Objective To investigate the shape of the causal relation between body mass index (BMI) and mortality.
Design Linear and non-linear mendelian randomisation analyses.
Setting Nord-Trøndelag Health (HUNT) Study (Norway) and UK Biobank (United Kingdom).
Participants Middle to early late aged participants of European descent: 56 150 from the HUNT Study and 366 385 from UK Biobank.
Main outcome measures All cause and cause specific (cardiovascular, cancer, and non-cardiovascular non-cancer) mortality.
Results 12 015 and 10 344 participants died during a median of 18.5 and 7.0 years of follow-up in the HUNT Study and UK Biobank, respectively. Linear mendelian randomisation analyses indicated an overall positive association between genetically predicted BMI and the risk of all cause mortality. An increase of 1 unit in genetically predicted BMI led to a 5% (95% confidence interval 1% to 8%) higher risk of mortality in overweight participants (BMI 25.0-29.9) and a 9% (4% to 14%) higher risk of mortality in obese participants (BMI ≥30.0) but a 34% (16% to 48%) lower risk in underweight (BMI <18.5) and a 14% (−1% to 27%) lower risk in low normal weight participants (BMI 18.5-19.9). Non-linear mendelian randomisation indicated a J shaped relation between genetically predicted BMI and the risk of all cause mortality, with the lowest risk at a BMI of around 22-25 for the overall sample. Subgroup analyses by smoking status, however, suggested an always-increasing relation of BMI with mortality in never smokers and a J shaped relation in ever smokers.
Conclusions The previously observed J shaped relation between BMI and risk of all cause mortality appears to have a causal basis, but subgroup analyses by smoking status revealed that the BMI-mortality relation is likely comprised of at least two distinct curves, rather than one J shaped relation. An increased risk of mortality for being underweight was only evident in ever smokers. | |
dc.language | EN | |
dc.publisher | B M J Group | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses | |
dc.type | Journal article | |
dc.creator.author | Sun, Yi-Qian | |
dc.creator.author | Burgess, Stephen | |
dc.creator.author | Staley, James R. | |
dc.creator.author | Wood, Angela M. | |
dc.creator.author | Bell, Steven | |
dc.creator.author | Kaptoge, Stephen | |
dc.creator.author | Guo, Qi | |
dc.creator.author | Bolton, Thomas R. | |
dc.creator.author | Mason, Amy M | |
dc.creator.author | Butterworth, Adam S. | |
dc.creator.author | Di Angelantonio, Emanuele | |
dc.creator.author | Vie, Gunnhild Åberge | |
dc.creator.author | Bjørngaard, Johan Håkon | |
dc.creator.author | Kinge, Jonas Minet | |
dc.creator.author | Chen, Yue | |
dc.creator.author | Mai, Xiao-Mei | |
cristin.unitcode | 185,52,11,0 | |
cristin.unitname | Avdeling for helseledelse og helseøkonomi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1690843 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ-BRITISH MEDICAL JOURNAL&rft.volume=364&rft.spage=&rft.date=2019 | |
dc.identifier.jtitle | BMJ-BRITISH MEDICAL JOURNAL | |
dc.identifier.doi | https://doi.org/10.1136/bmj.l1042 | |
dc.identifier.urn | URN:NBN:no-71614 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1756-1833 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/68459/1/Sun_2019_MR_BMI_acm_NTNU_Open.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 364 | |