dc.date.accessioned | 2019-05-08T14:24:12Z | |
dc.date.available | 2019-05-08T14:24:12Z | |
dc.date.created | 2018-06-21T09:57:59Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Dejgaard, Lars Håland, Trine Synnøve Fink Lie, Øyvind Haugen Ribe, Margareth Bjune, Thea Leren, Ida Skrinde Berge, Knut Erik Edvardsen, Thor Haugaa, Kristina . Vigorous exercise in patients with hypertrophic cardiomyopathy. International Journal of Cardiology. 2018, 250, 157-163 | |
dc.identifier.uri | http://hdl.handle.net/10852/67920 | |
dc.description.abstract | Background: We aimed to investigate if history of vigorous exercise was associated with changes in left ventricular morphology, left ventricular function and ventricular arrhythmias (VAs) in hypertrophic cardiomyopathy genotype positive, phenotype negative (Genotype+ LVH−) and in phenotype positive (HCM LVH+).
Methods: In this cross sectional study we included 187 subjects (age 49 ± 16 years, 89(48%) female, 121(65%) HCM LVH+ and 66 (35%) Genotype+ LVH-) who answered a questionnaire on physical activity history. Exercise ≥6 metabolic equivalents was defined as vigorous. Subjects with a history of vigorous exercise ≥4 h/week during ≥6 years were defined as athletes. All underwent echocardiography and Holter monitoring. VAs were defined as aborted cardiac arrest, sustained or non-sustained ventricular tachycardia.
Results: In both Genotype+ LVH− and HCM LVH+, lifetime vigorous exercise correlated with larger left ventricular end-diastolic volume (rho 0.44 and 0.38 respectively, both p b 0.001). Lifetime vigorous exercise correlated with increased left ventricular mass in Genotype+ LVH− (rho 0.28, p = 0.03), but not in HCM LVH+ (p = 0.53). Left ventricular systolic function was similar between athletes and non-athletes in Genotype+ LVH− and HCM LVH+. HCM LVH+ athletes had lower E/e' (p = 0.03) and higher e' (p = 0.02) compared to non-athletes, while this difference was not observed in Genotype+ LVH−. Lifetime vigorous exercise was similar among HCM LVH+ with and without VAs (p = 0.89).
Conclusions: Increased lifetime vigorous exercise was associated with larger left ventricular volumes in hypertrophic cardiomyopathy, but correlated to left ventricular mass only in Genotype+ LVH−. Vigorous exercise was associated with favorable diastolic function in HCM LVH+, and was not associated with VAs. | en_US |
dc.language | EN | |
dc.publisher | Elsevier Science | |
dc.relation.ispartof | Dejgaard, Lars (2020) Cardiac diseases with risk of severe ventricular arrhythmias; risk stratification and impact of exercise. Doctoral thesis http://hdl.handle.net/10852/74337 | |
dc.relation.uri | http://hdl.handle.net/10852/74337 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Vigorous exercise in patients with hypertrophic cardiomyopathy | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Dejgaard, Lars | |
dc.creator.author | Håland, Trine Synnøve Fink | |
dc.creator.author | Lie, Øyvind Haugen | |
dc.creator.author | Ribe, Margareth | |
dc.creator.author | Bjune, Thea | |
dc.creator.author | Leren, Ida Skrinde | |
dc.creator.author | Berge, Knut Erik | |
dc.creator.author | Edvardsen, Thor | |
dc.creator.author | Haugaa, Kristina | |
cristin.unitcode | 185,53,15,13 | |
cristin.unitname | Kardiologisk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1592820 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International Journal of Cardiology&rft.volume=250&rft.spage=157&rft.date=2018 | |
dc.identifier.jtitle | International Journal of Cardiology | |
dc.identifier.volume | 250 | |
dc.identifier.startpage | 157 | |
dc.identifier.endpage | 163 | |
dc.identifier.doi | http://dx.doi.org/10.1016/j.ijcard.2017.07.015 | |
dc.identifier.urn | URN:NBN:no-71091 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0167-5273 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/67920/1/Dejgaard_et_al-2017-Int%2BJ%2BCardiol_HCM%2BExercise.pdf | |
dc.type.version | PublishedVersion | |