dc.date.accessioned | 2019-04-23T11:12:56Z | |
dc.date.available | 2019-04-23T11:12:56Z | |
dc.date.created | 2019-01-16T16:52:56Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Moser, N Rodriguez-Manzano, M. Lande, Tor Sverre Georgiou, P. . A scalable ISFET sensing and memory array with sensor auto-calibration for on-chip real-time DNA detection. IEEE Transactions on Biomedical Circuits and Systems. 2018, 12(2), 390-401 | |
dc.identifier.uri | http://hdl.handle.net/10852/67778 | |
dc.description.abstract | This paper presents a novel CMOS-based system-onchip with a 78 × 56 ion-sensitive field-effect transistor array using in-pixel quantization and compensation of sensor nonidealities. The pixel integrates sensing circuitry and memory cells to encode the ion concentration in time and store a calibration value per pixel. Temperature sensing pixels spread throughout the array allow temperature monitoring during the reaction. We describe the integration of the array as part of a lab-on-chip cartridge that plugs into a motherboard for power management, biasing, data acquisition, and temperature regulation. This forms a robust ion detection platform, which is demonstrated as a pH sensing system. We show that our calibration is able to perform readout with a linear spread of 0.3% and that the system exhibits a high pH sensitivity of 3.2 µs/pH. The complete system is shown to perform on-chip realtime DNA amplification and detection of lambda phage DNA by loop-mediated isothermal amplification. | en_US |
dc.language | EN | |
dc.publisher | Institute of Electrical and Electronics Engineers (IEEE) | |
dc.rights | Attribution 3.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.title | A scalable ISFET sensing and memory array with sensor auto-calibration for on-chip real-time DNA detection | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Moser, N | |
dc.creator.author | Rodriguez-Manzano, M. | |
dc.creator.author | Lande, Tor Sverre | |
dc.creator.author | Georgiou, P. | |
cristin.unitcode | 185,15,5,40 | |
cristin.unitname | Forskningsgruppen for nanoelektronikksystemer | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1658666 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=IEEE Transactions on Biomedical Circuits and Systems&rft.volume=12&rft.spage=390&rft.date=2018 | |
dc.identifier.jtitle | IEEE Transactions on Biomedical Circuits and Systems | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 390 | |
dc.identifier.endpage | 401 | |
dc.identifier.doi | http://dx.doi.org/10.1109/TBCAS.2017.2789161 | |
dc.identifier.urn | URN:NBN:no-70940 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-4545 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/67778/1/08278828.pdf | |
dc.type.version | PublishedVersion | |