dc.date.accessioned | 2019-04-15T07:45:50Z | |
dc.date.available | 2019-04-15T07:45:50Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | http://hdl.handle.net/10852/67677 | |
dc.description.abstract | Hemolytic-uremic syndrome (HUS) is a severe clinical syndrome defined by impaired renal function, hemolytic anemia and thrombocytopenia. It mainly affects children of pre-school age, and is one of the most common causes of pediatric acute kidney injury (AKI) in Europe. HUS can be classified by clinical presentation as diarrhea-associated (D+HUS) or not (D-HUS). D+HUS constitute around 90 % of cases and is primarily caused by infection with Shiga toxin-producing Escherichia coli (STEC). Both conditions are under epidemiological surveillance in Norway.
The first national Norwegian outbreak of STEC-related HUS occurred in 2006; ten children developed HUS, one with a fatal outcome. This brought HUS to national public attention and led to mandatory notification of all D+HUS to the Norwegian Surveillance System for Communicable Disease (MSIS).
The aims of this thesis was to examine central aspects of HUS in children in Norway, focusing on the areas of epidemiology, surveillance, clinical presentation, and outcome, expanded to include surveillance of STEC and epidemiology of pediatric AKI. Data was gathered through a retrospective review of medical records (1999-2008) and cases notified to MSIS (2007-2017).
The main findings indicate an underestimating of pediatric HUS occurrence in Norway prior to 2006, but a lower incidence rate compared to other countries. The data also suggest general underreporting of STEC. This is further reinforced by a stable notification rate of HUS and increased rate of “low-virulent” (non-HUS-associated) STEC cases that was linked to implementation of novel STEC identification methods. A high rate and variation of complications in HUS cases is shown. HUS was the second most common cause of AKI in the pediatric population.
Overall, these findings emphasize the importance of mandatory notification, surveillance and tailored control measures for both HUS and STEC, and may contribute to the general understanding of HUS. | en_US |
dc.language.iso | en | en_US |
dc.relation.haspart | Paper I: Jenssen GR, Hovland E, Bjerre A, Bangstad HJ, Nygard K, Vold L. Incidence and etiology of hemolytic-uremic syndrome in children in Norway, 1999-2008--a retrospective study of hospital records to assess the sensitivity of surveillance. BMC Infect Dis. 2014 May 16;14:265. DOI: 10.1186/1471-2334-14-265. The paper is included in the thesis. Also available in DUO http://urn.nb.no/URN:NBN:no-46601 | |
dc.relation.haspart | Paper II: Jenssen GR, Veneti L, Naseer U, Lange H, Vold L, Brandal LT. Implementation of multiplex PCR diagnostics for gastrointestinal pathogens linked to increase of notified Shiga toxin-producing Escherichia coli cases in Norway, 2007-2017. Submitted. To be published. The paper is not available in DUO awaiting publishing. | |
dc.relation.haspart | Paper III: Jenssen GR, Vold L, Hovland E, Bangstad HJ, Nygard K, Bjerre A. A nationwide study of clinical, therapeutical and long-term aspects of hemolytic-uremic syndrome in children in Norway, 1999-2008. BMC Infect Dis. 2016 Jun 13;16:285. DOI: 10.1186/s12879-016-1627-7. The paper is included in the thesis. Also available in DUO http://urn.nb.no/URN:NBN:no-54054 | |
dc.relation.haspart | Paper IV: Jenssen GR, Hovland E, Bangstad HJ, Nygard K, Vold L, Bjerre A. The incidence and aetiology of acute kidney injury in children in Norway between 1999 and 2008. Acta Paediatr. 2014 Jul 10;103(11):1192-7. DOI: 10.1111/apa.12742. The paper is included in the thesis. Also available at: https://doi.org/10.1111/apa.12742 | |
dc.relation.uri | http://urn.nb.no/URN:NBN:no-46601 | |
dc.relation.uri | http://urn.nb.no/URN:NBN:no-54054 | |
dc.relation.uri | https://doi.org/10.1111/apa.12742 | |
dc.title | Hemolytic-uremic syndrome in children in Norway: a study on epidemiology, surveillance, clinical aspects and outcome | en_US |
dc.type | Doctoral thesis | en_US |
dc.creator.author | Jenssen, Gaute Reier | |
dc.identifier.urn | URN:NBN:no-70847 | |
dc.type.document | Doktoravhandling | en_US |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/67677/1/PhD-Reier-Jenssen-2019.pdf | |