dc.date.accessioned | 2019-02-27T19:23:16Z | |
dc.date.available | 2019-02-27T19:23:16Z | |
dc.date.created | 2018-10-17T13:23:11Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Zotcheva, Ekaterina Bergh, Sverre Selbæk, Geir Krokstad, Steinar Håberg, Asta Strand, Bjørn Heine Ernstsen, Linda . Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study. Journal of Alzheimer's Disease. 2018 | |
dc.identifier.uri | http://hdl.handle.net/10852/66851 | |
dc.description.abstract | Background: Physical activity (PA) is associated with a decreased dementia risk, whereas psychological distress (distress) is linked to an increased dementia risk.
Objective: We investigated independent and joint associations of midlife moderate-to-vigorous PA (MVPA) and distress with incident dementia.
Methods: Our study comprised 28,916 participants aged 30–60 years from the Nord-Trøndelag Health Study (HUNT1, 1984–1986). Data on MVPA and distress from HUNT1 was linked to the Health and Memory Study in Nord-Trøndelag for dementia case identification. Participants were followed from 1995 until 2011. We used adjusted Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI).
Results: In fully adjusted analyses, MVPA was associated with a reduced dementia risk (HR 0.81, 95% CI 0.62–1.06), compared to no MVPA. Distress was associated with an increased dementia risk (HR 1.30, 95% CI 0.99–1.70). Compared to distressed participants not taking part in MVPA, non-distressed no-MVPA participants had a reduced dementia risk (HR 0.72, 95% CI 0.54–0.96). The same applied to distressed MVPA participants (HR 0.50, 95% CI 0.22–1.14), and non-distressed MVPA participants (HR 0.63, 95% CI 0.44–0.90). Our results indicated an additive interaction between MVPA and distress on dementia risk.
Conclusion: Our results suggest that midlife MVPA reduces risk of incident dementia among both distressed and non-distressed individuals.
© 2018 IOS Press | en_US |
dc.language | EN | |
dc.publisher | IOS Press | |
dc.title | Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study | en_US |
dc.title.alternative | ENEngelskEnglishMidlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study | |
dc.type | Journal article | en_US |
dc.creator.author | Zotcheva, Ekaterina | |
dc.creator.author | Bergh, Sverre | |
dc.creator.author | Selbæk, Geir | |
dc.creator.author | Krokstad, Steinar | |
dc.creator.author | Håberg, Asta | |
dc.creator.author | Strand, Bjørn Heine | |
dc.creator.author | Ernstsen, Linda | |
cristin.unitcode | 185,52,12,0 | |
cristin.unitname | Avdeling for sykepleievitenskap | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1621069 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Alzheimer's Disease&rft.volume=&rft.spage=&rft.date=2018 | |
dc.identifier.jtitle | Journal of Alzheimer's Disease | |
dc.identifier.pagecount | 9 | |
dc.identifier.doi | http://dx.doi.org/10.3233/JAD-180768 | |
dc.identifier.urn | URN:NBN:no-70033 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1387-2877 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/66851/2/MVPA_PD_Dem_final.pdf | |
dc.type.version | AcceptedVersion | |