Browsing Psykologisk institutt by Author "O'Connell, Kevin Sean"

Now showing items 1-6 of 6

  • Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology 
    van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin Sean; Bettella, Francesco; Djurovic, Srdjan; Wolfers, Thomas; Alnæs, Dag; Agartz, Ingrid; Smeland, Olav Bjerkehagen; Melle, Ingrid; Sánchez, Jennifer Monereo; Linden, David E.J.; Dale, Anders; Westlye, Lars Tjelta; Andreassen, Ole; Frei, Oleksandr; Kaufmann, Tobias (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite ...
  • Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood 
    Askeland, Ragna Bugge; Hannigan, Laurie John; O'Connell, Kevin Sean; Corfield, Elizabeth Claire; Frei, Oleksandr; Thapar, Anita; Smith, George Davey; Reichborn-Kjennerud, Ted; Andreassen, Ole; Ask, Helga; Havdahl, Alexandra (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Knowledge on how genetic risk for bipolar disorder manifests in developmental, emotional or behavioral traits during childhood is lacking. This issue is important to address to inform early detection and intervention ...
  • Genetic Overlap Between Alzheimer’s Disease and Depression Mapped Onto the Brain 
    Monereo-Sánchez, Jennifer; Schram, Miranda T.; Frei, Oleksandr; O'Connell, Kevin Sean; Shadrin, Alexey; Smeland, Olav Bjerkehagen; Westlye, Lars Tjelta; Andreassen, Ole; Kaufmann, Tobias; Linden, David E. J.; van der Meer, Dennis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background: Alzheimer’s disease (AD) and depression are debilitating brain disorders that are often comorbid. Shared brain mechanisms have been implicated, yet findings are inconsistent, reflecting the complexity of the ...
  • Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation 
    Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ...
  • Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood 
    Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Wang, Yunpeng; Shadrin, Alexey; Alnæs, Dag; Bahrami, Shahram; Lin, Aihua; Karadag, Naz; Holen, Børge; Fernández-Cabello, Sara; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Westlye, Lars Tjelta; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
    Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric ...
  • Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation 
    Sheikh, Mashhood Ahmed; O'Connell, Kevin Sean; Lekva, Tove; Szabo, Attila; Akkouh, Ibrahim Ahmed; Osete, Jordi Requena; Agartz, Ingrid; Engh, John; Andreou, Dimitrios; Boye, Birgitte; Bøen, Erlend; Elvsåshagen, Torbjørn; Hope, Sigrun; Werner, Maren Caroline Frogner; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Melle, Ingrid; Drange, Ole Kristian; Morken, Gunnar; Nærland, Terje; Sørensen, Kjetil; Vaaler, Arne; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Aukrust, Pål; Djurovic, Srdjan; Steen, Nils Eiel; Andreassen, Ole; Ueland, Thor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Cell adhesion molecules (CAMs) orchestrate leukocyte trafficking and could link peripheral and neuroinflammation in patients with severe mental illness (SMI), by promoting inflammatory and immune-mediated ...