dc.date.accessioned | 2018-11-29T12:46:07Z | |
dc.date.available | 2018-11-29T12:46:07Z | |
dc.date.created | 2018-03-23T14:09:06Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | La Cour Poulsen, Lars Edelmann, Reidunn Jetne Krüger, Stig Diéguez-Hurtado, Rodrigo Shah, Akshay Stav-Noraas, Tor Espen Renzi, Anastasia Szymanska, Monika Wang, Junbai Ehling, Manuel Benedito, Rui Kasprzycka, Monika Bækkevold, Espen Sønderaal Sundnes, Olav Midwood, Kim S. Scott, Helge Collas, Philippe Siebel, Christian W. Adams, Ralf H. Haraldsen, Guttorm Sundlisæter, Eirik Hol, Johanna . Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers. Arteriosclerosis, Thrombosis and Vascular Biology. 2018, 38(4), 854-869 | |
dc.identifier.uri | http://hdl.handle.net/10852/65822 | |
dc.description.abstract | Objective: Endothelial upregulation of adhesion molecules serves to recruit leukocytes to inflammatory sites and appears to be promoted by NOTCH1; however, current models based on interactions between active NOTCH1 and NF-κB components cannot explain the transcriptional selectivity exerted by NOTCH1 in this context.
Approach and Results: Observing that Cre/Lox-induced conditional mutations of endothelial Notch modulated inflammation in murine contact hypersensitivity, we found that IL (interleukin)-1β stimulation induced rapid recruitment of RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A) to genomic sites occupied by NOTCH1-RBPJ (recombination signal-binding protein for immunoglobulin kappa J region) and that NOTCH1 knockdown reduced histone H3K27 acetylation at a subset of NF-κB–directed inflammatory enhancers.
Conclusions: Our findings reveal that NOTCH1 signaling supports the expression of a subset of inflammatory genes at the enhancer level and demonstrate how key signaling pathways converge on chromatin to coordinate the transition to an infla mmatory endothelial phenotype. | en_US |
dc.language | EN | |
dc.title | Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers | en_US |
dc.title.alternative | ENEngelskEnglishInhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers | |
dc.type | Journal article | en_US |
dc.creator.author | La Cour Poulsen, Lars | |
dc.creator.author | Edelmann, Reidunn Jetne | |
dc.creator.author | Krüger, Stig | |
dc.creator.author | Diéguez-Hurtado, Rodrigo | |
dc.creator.author | Shah, Akshay | |
dc.creator.author | Stav-Noraas, Tor Espen | |
dc.creator.author | Renzi, Anastasia | |
dc.creator.author | Szymanska, Monika | |
dc.creator.author | Wang, Junbai | |
dc.creator.author | Ehling, Manuel | |
dc.creator.author | Benedito, Rui | |
dc.creator.author | Kasprzycka, Monika | |
dc.creator.author | Bækkevold, Espen Sønderaal | |
dc.creator.author | Sundnes, Olav | |
dc.creator.author | Midwood, Kim S. | |
dc.creator.author | Scott, Helge | |
dc.creator.author | Collas, Philippe | |
dc.creator.author | Siebel, Christian W. | |
dc.creator.author | Adams, Ralf H. | |
dc.creator.author | Haraldsen, Guttorm | |
dc.creator.author | Sundlisæter, Eirik | |
dc.creator.author | Hol, Johanna | |
cristin.unitcode | 185,51,12,0 | |
cristin.unitname | Avdeling for molekylærmedisin | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1575382 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Arteriosclerosis, Thrombosis and Vascular Biology&rft.volume=38&rft.spage=854&rft.date=2018 | |
dc.identifier.jtitle | Arteriosclerosis, Thrombosis and Vascular Biology | |
dc.identifier.volume | 38 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 854 | |
dc.identifier.endpage | 869 | |
dc.identifier.doi | http://dx.doi.org/10.1161/ATVBAHA.117.310388 | |
dc.identifier.urn | URN:NBN:no-68217 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1079-5642 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/65822/2/La%2BCour%2BPoulsen%2Bet%2Bal_Cristin-post%2B1575382.pdf | |
dc.type.version | AcceptedVersion | |