dc.date.accessioned | 2018-10-08T14:49:25Z | |
dc.date.available | 2018-10-08T14:49:25Z | |
dc.date.created | 2018-08-13T10:20:52Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Lagali, Neil S. Allgeier, Stephan Guimarães, Pedro Badian, Reza Ruggeri, Alfredo Köhler, Bernd Utheim, Tor Paaske Peebo, Beatrice Peterson, Magnus Dahlin, Lars B. Rolandsson, Olov . Data Descriptor: Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations. Scientific Data. 2018, 5:180075, 1-12 | |
dc.identifier.uri | http://hdl.handle.net/10852/65089 | |
dc.description.abstract | A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabetes and its complications. Here, we use machine-based algorithms to provide wide-area mosaics of the cornea’s subbasal nerve plexus (SBP) also accounting for depth (axial) fluctuation of the plexus. Degradation of the SBP with age has been mitigated as a confounding factor by providing a dataset comprising healthy and type 2 diabetes subjects of the same age. To maximize reuse, the dataset includes bilateral eye data, associated clinical parameters, and machine-generated SBP nerve density values obtained through automatic segmentation and nerve tracing algorithms. The dataset can be used to examine nerve degradation patterns to develop tools to non-invasively monitor diabetes progression while avoiding narrow-field imaging and image selection biases. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Data Descriptor: Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations | en_US |
dc.title.alternative | ENEngelskEnglishData Descriptor: Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations | |
dc.type | Journal article | en_US |
dc.creator.author | Lagali, Neil S. | |
dc.creator.author | Allgeier, Stephan | |
dc.creator.author | Guimarães, Pedro | |
dc.creator.author | Badian, Reza | |
dc.creator.author | Ruggeri, Alfredo | |
dc.creator.author | Köhler, Bernd | |
dc.creator.author | Utheim, Tor Paaske | |
dc.creator.author | Peebo, Beatrice | |
dc.creator.author | Peterson, Magnus | |
dc.creator.author | Dahlin, Lars B. | |
dc.creator.author | Rolandsson, Olov | |
cristin.unitcode | 185,50,0,0 | |
cristin.unitname | Det medisinske fakultet | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1601414 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Data&rft.volume=5:180075&rft.spage=1&rft.date=2018 | |
dc.identifier.jtitle | Scientific Data | |
dc.identifier.volume | 5:180075 | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 12 | |
dc.identifier.doi | http://dx.doi.org/10.1038/sdata.2018.75 | |
dc.identifier.urn | URN:NBN:no-67622 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2052-4463 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/65089/1/Data%2BDescriptor%2BWide-field%2Bcorneal%2Bsubbasal%2Bnerve%2Bplexus%2Bmosaics%2Bin%2Bage-controlled%2Bhealthy%2Band%2Btype%2B2%2Bdiabetes%2Bpopulations.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | EU/316990 | |