Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
dc.date.accessioned | 2018-09-06T11:02:29Z | |
dc.date.available | 2018-09-06T11:02:29Z | |
dc.date.created | 2018-01-04T11:07:43Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Asim, Mohammad Tarish, Firas Zecchini, Heather I. Sanjiv, Kumar Gelali, Eleni Massie, Charles E. Baridi, Ajoeb Warren, Anne Y. Zhao, Wanfeng Ogris, Christoph McDuffus, Leigh-Anne Mascalchi, Patrice Shaw, Greg Dev, Harveer Wadhwa, Karan Wijnhoven, Paul Forment, Josep V Lyons, Scott R Lynch, Andy G. O'Neill, Cormac Zecchini, Vincent R. Rennie, Paul S. Baniahmad, Aria Tavare, Simon Mills, Ian Geoffrey Galanty, Yaron Crosetto, Nicola Schultz, Niklas Neal, David Helleday, Thomas . Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. Nature Communications. 2017, 8(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/64163 | |
dc.description.abstract | Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we demonstrate a direct requirement for the androgen receptor (AR) to maintain HR gene expression and HR activity in prostate cancer. We show that PARP-mediated repair pathways are upregulated in prostate cancer following androgen-deprivation therapy (ADT). Furthermore, upregulation of PARP activity is essential for the survival of prostate cancer cells and we demonstrate a synthetic lethality between ADT and PARP inhibition in vivo. Our data suggest that ADT can functionally impair HR prior to the development of castration resistance and that, this potentially could be exploited therapeutically using PARP inhibitors in combination with androgen-deprivation therapy upfront in advanced or high-risk prostate cancer. | en_US |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Asim, Mohammad | |
dc.creator.author | Tarish, Firas | |
dc.creator.author | Zecchini, Heather I. | |
dc.creator.author | Sanjiv, Kumar | |
dc.creator.author | Gelali, Eleni | |
dc.creator.author | Massie, Charles E. | |
dc.creator.author | Baridi, Ajoeb | |
dc.creator.author | Warren, Anne Y. | |
dc.creator.author | Zhao, Wanfeng | |
dc.creator.author | Ogris, Christoph | |
dc.creator.author | McDuffus, Leigh-Anne | |
dc.creator.author | Mascalchi, Patrice | |
dc.creator.author | Shaw, Greg | |
dc.creator.author | Dev, Harveer | |
dc.creator.author | Wadhwa, Karan | |
dc.creator.author | Wijnhoven, Paul | |
dc.creator.author | Forment, Josep V | |
dc.creator.author | Lyons, Scott R | |
dc.creator.author | Lynch, Andy G. | |
dc.creator.author | O'Neill, Cormac | |
dc.creator.author | Zecchini, Vincent R. | |
dc.creator.author | Rennie, Paul S. | |
dc.creator.author | Baniahmad, Aria | |
dc.creator.author | Tavare, Simon | |
dc.creator.author | Mills, Ian Geoffrey | |
dc.creator.author | Galanty, Yaron | |
dc.creator.author | Crosetto, Nicola | |
dc.creator.author | Schultz, Niklas | |
dc.creator.author | Neal, David | |
dc.creator.author | Helleday, Thomas | |
cristin.unitcode | 185,57,0,0 | |
cristin.unitname | Norsk Senter for Molekylærmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1535603 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=8&rft.spage=&rft.date=2017 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 8 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | http://dx.doi.org/10.1038/s41467-017-00393-y | |
dc.identifier.urn | URN:NBN:no-66722 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/64163/4/s41467-017-00393-y.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/144182 |
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