dc.date.accessioned | 2018-08-31T10:48:34Z | |
dc.date.available | 2018-08-31T10:48:34Z | |
dc.date.created | 2018-01-24T11:05:09Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Antoniali, Giulia Serra, Fabrizio Lirussi, Lisa Tanaka, Mikiei D'Ambrosio, Chiara Zhang, Shiheng Radovic, Slobodanka Dalla, Emiliano Ciani, Yari Scaloni, Andrea Li, Mengxia Piazza, Silvano Tell, Gianluca . Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Nature Communications. 2017, 8(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/64028 | |
dc.description.abstract | Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxidative stress responses, tumor progression and chemoresistance. However, the molecular mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still unclear. Recent findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism. Through the characterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other proteins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA processing and stability via association with the DROSHA-processing complex during genotoxic stress. We also show that endonuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the processing of miR-221/222 in regulating expression of the tumor suppressor PTEN. Analysis of a cohort of different cancers supports the relevance of our findings for tumor biology. We also show that apurinic/apyrimidinic endonuclease 1 participates in RNA-interactomes and protein-interactomes involved in cancer development, thus indicating an unsuspected post-transcriptional effect on cancer genes. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Antoniali, Giulia | |
dc.creator.author | Serra, Fabrizio | |
dc.creator.author | Lirussi, Lisa | |
dc.creator.author | Tanaka, Mikiei | |
dc.creator.author | D'Ambrosio, Chiara | |
dc.creator.author | Zhang, Shiheng | |
dc.creator.author | Radovic, Slobodanka | |
dc.creator.author | Dalla, Emiliano | |
dc.creator.author | Ciani, Yari | |
dc.creator.author | Scaloni, Andrea | |
dc.creator.author | Li, Mengxia | |
dc.creator.author | Piazza, Silvano | |
dc.creator.author | Tell, Gianluca | |
cristin.unitcode | 185,53,82,10 | |
cristin.unitname | Avdeling for klinisk molekylærbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1550674 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=8&rft.spage=&rft.date=2017 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 8 | |
dc.identifier.doi | http://dx.doi.org/10.1038/s41467-017-00842-8 | |
dc.identifier.urn | URN:NBN:no-66566 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/64028/1/s41467-017-00842-8.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 797 | |