dc.date.accessioned | 2018-08-30T12:58:26Z | |
dc.date.available | 2018-08-30T12:58:26Z | |
dc.date.created | 2018-01-29T13:33:57Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Thompson, Elise Holter Lensjø, Kristian Kinden Wigestrand, Mattis B Malthe-Sørenssen, Anders Hafting, Torkel Fyhn, Marianne . Removal of perineuronal nets disrupts recall of a remote fear memory. Proceedings of the National Academy of Sciences of the United States of America. 2017, 115(3), 607-612 | |
dc.identifier.uri | http://hdl.handle.net/10852/63987 | |
dc.description.abstract | Throughout life animals learn to recognize cues that signal danger and instantaneously initiate an adequate threat response. Memories of such associations may last a lifetime and far outlast the intracellular molecules currently found to be important for memory processing. The memory engram may be supported by other more stable molecular components, such as the extracellular matrix structure of perineuronal nets (PNNs). Here, we show that recall of remote, but not recent, visual fear memories in rats depend on intact PNNs in the secondary visual cortex (V2L). Supporting our behavioral findings, increased synchronized theta oscillations between V2L and basolateral amygdala, a physiological correlate of successful recall, was absent in rats with degraded PNNs in V2L. Together, our findings suggest a role for PNNs in remote memory processing by stabilizing the neural network of the engram. | en_US |
dc.language | EN | |
dc.relation.ispartof | Thompson, Elise Holter (2020) Perineuronal nets in memory processing and behavior. Doctoral thesis http://hdl.handle.net/10852/81655 | |
dc.relation.uri | http://hdl.handle.net/10852/81655 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Removal of perineuronal nets disrupts recall of a remote fear memory | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Thompson, Elise Holter | |
dc.creator.author | Lensjø, Kristian Kinden | |
dc.creator.author | Wigestrand, Mattis B | |
dc.creator.author | Malthe-Sørenssen, Anders | |
dc.creator.author | Hafting, Torkel | |
dc.creator.author | Fyhn, Marianne | |
cristin.unitcode | 185,15,29,30 | |
cristin.unitname | Seksjon for fysiologi og cellebiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1554697 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings of the National Academy of Sciences of the United States of America&rft.volume=115&rft.spage=607&rft.date=2017 | |
dc.identifier.jtitle | Proceedings of the National Academy of Sciences of the United States of America | |
dc.identifier.volume | 115 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 607 | |
dc.identifier.endpage | 612 | |
dc.identifier.doi | http://dx.doi.org/10.1073/pnas.1713530115 | |
dc.identifier.urn | URN:NBN:no-66524 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0027-8424 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/63987/2/PNAS-2017-Thompson-1713530115.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/143730 | |
dc.relation.project | NFR/549217 | |
dc.relation.project | NFR/231248 | |