Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins
dc.date.accessioned | 2018-08-20T12:47:26Z | |
dc.date.available | 2018-08-20T12:47:26Z | |
dc.date.created | 2017-11-03T12:24:54Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Bulanova, Daria Ianevski, Aleksandr Bugai, Andrii Akimov, Yevhen Kuivanen, Suvi Paavilainen, Henrik Kakkola, Laura Nandania, Jatin Turunen, Laura Ohman, Tiina Ala-Hongisto, Hanna Pesonen, Hanna M Kuisma, Marika S Honkimaa, Anni Walton, Emma Louise Oksenych, Valentyn Lorey, Martina B. Guschin, Dmitry Shim, Jungmin Kim, Jinhee Than, Thoa T Chang, So Young Hukkanen, Veijo Kulesskiy, Evgeny Marjomaki, Varpu S Julkunen, Ilkka Nyman, Tuula Anneli Matikainen, Sampsa Saarela, Jani S Sane, Famara Hober, Didier Gabriel, Gulsah De Brabander, Jef K Martikainen, Miika Windisch, Marc P Min, Ji-Young Bruzzone, Roberto Aittokallio, Tero Vaha-Koskela, Markus Vapalahti, Olli Pulk, Arto Velagapudi, Vidya Kainov, Denis . Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins. Viruses. 2017, 9(10) | |
dc.identifier.uri | http://hdl.handle.net/10852/63244 | |
dc.description.abstract | Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensitizes cells containing foreign RNA or DNA to apoptosis. A comparison of the toxicity, antiviral activity, and side effects of six Bcl-2i allowed us to select A-1155463 as an antiviral lead candidate. Thus, our results pave the way for the further development of Bcl-2i for the prevention and treatment of viral diseases. | en_US |
dc.language | EN | |
dc.publisher | MDPI AG | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins | en_US |
dc.title.alternative | ENEngelskEnglishAntiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins | |
dc.type | Journal article | en_US |
dc.creator.author | Bulanova, Daria | |
dc.creator.author | Ianevski, Aleksandr | |
dc.creator.author | Bugai, Andrii | |
dc.creator.author | Akimov, Yevhen | |
dc.creator.author | Kuivanen, Suvi | |
dc.creator.author | Paavilainen, Henrik | |
dc.creator.author | Kakkola, Laura | |
dc.creator.author | Nandania, Jatin | |
dc.creator.author | Turunen, Laura | |
dc.creator.author | Ohman, Tiina | |
dc.creator.author | Ala-Hongisto, Hanna | |
dc.creator.author | Pesonen, Hanna M | |
dc.creator.author | Kuisma, Marika S | |
dc.creator.author | Honkimaa, Anni | |
dc.creator.author | Walton, Emma Louise | |
dc.creator.author | Oksenych, Valentyn | |
dc.creator.author | Lorey, Martina B. | |
dc.creator.author | Guschin, Dmitry | |
dc.creator.author | Shim, Jungmin | |
dc.creator.author | Kim, Jinhee | |
dc.creator.author | Than, Thoa T | |
dc.creator.author | Chang, So Young | |
dc.creator.author | Hukkanen, Veijo | |
dc.creator.author | Kulesskiy, Evgeny | |
dc.creator.author | Marjomaki, Varpu S | |
dc.creator.author | Julkunen, Ilkka | |
dc.creator.author | Nyman, Tuula Anneli | |
dc.creator.author | Matikainen, Sampsa | |
dc.creator.author | Saarela, Jani S | |
dc.creator.author | Sane, Famara | |
dc.creator.author | Hober, Didier | |
dc.creator.author | Gabriel, Gulsah | |
dc.creator.author | De Brabander, Jef K | |
dc.creator.author | Martikainen, Miika | |
dc.creator.author | Windisch, Marc P | |
dc.creator.author | Min, Ji-Young | |
dc.creator.author | Bruzzone, Roberto | |
dc.creator.author | Aittokallio, Tero | |
dc.creator.author | Vaha-Koskela, Markus | |
dc.creator.author | Vapalahti, Olli | |
dc.creator.author | Pulk, Arto | |
dc.creator.author | Velagapudi, Vidya | |
dc.creator.author | Kainov, Denis | |
cristin.unitcode | 185,53,18,12 | |
cristin.unitname | Avdeling for immunologi og transfusjonsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1510729 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Viruses&rft.volume=9&rft.spage=&rft.date=2017 | |
dc.identifier.jtitle | Viruses | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 10 | |
dc.identifier.doi | http://dx.doi.org/10.3390/v9100271 | |
dc.identifier.urn | URN:NBN:no-65801 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1999-4915 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/63244/1/Bulanova_Daria_2017.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 271 |
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