dc.date.accessioned | 2018-07-19T13:03:07Z | |
dc.date.available | 2018-07-19T13:03:07Z | |
dc.date.created | 2017-06-01T13:35:44Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Landsverk, Ole J. B. Snir, Omri Bartolome Casado, Raquel Richter, Lisa Maria Mold, Jeff E. Réu, Pedro Horneland, Rune Paulsen, Vemund Yaqub, Sheraz Aandahl, Einar Martin Øyen, Ole Thorarensen, Hildur Sif Salehpour, Mehran Possnert, Göran Frisén, Jonas Sollid, Ludvig Magne Bækkevold, Espen Sønderaal Jahnsen, Frode Lars . Antibody-secreting plasma cells persist for decades in human intestine. Journal of Experimental Medicine. 2017, 214(2), 309-317 | |
dc.identifier.uri | http://hdl.handle.net/10852/62347 | |
dc.description.abstract | Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19+ PC subset was dynamically exchanged, whereas of two CD19− PC subsets, CD45+ PCs exhibited little and CD45− PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45− PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19− PC subsets support selection and maintenance of protective PCs for life in human intestine. | en_US |
dc.language | EN | |
dc.relation.ispartof | Casado, Raquel Bartolomé (2020) Longevity of the adaptive immune cell compartment in the human small intestine. Doctoral thesis http://hdl.handle.net/10852/80686 | |
dc.relation.uri | http://hdl.handle.net/10852/80686 | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.title | Antibody-secreting plasma cells persist for decades in human intestine | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Landsverk, Ole J. B. | |
dc.creator.author | Snir, Omri | |
dc.creator.author | Bartolome Casado, Raquel | |
dc.creator.author | Richter, Lisa Maria | |
dc.creator.author | Mold, Jeff E. | |
dc.creator.author | Réu, Pedro | |
dc.creator.author | Horneland, Rune | |
dc.creator.author | Paulsen, Vemund | |
dc.creator.author | Yaqub, Sheraz | |
dc.creator.author | Aandahl, Einar Martin | |
dc.creator.author | Øyen, Ole | |
dc.creator.author | Thorarensen, Hildur Sif | |
dc.creator.author | Salehpour, Mehran | |
dc.creator.author | Possnert, Göran | |
dc.creator.author | Frisén, Jonas | |
dc.creator.author | Sollid, Ludvig Magne | |
dc.creator.author | Bækkevold, Espen Sønderaal | |
dc.creator.author | Jahnsen, Frode Lars | |
cristin.unitcode | 185,53,18,13 | |
cristin.unitname | Avdeling for patologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1473511 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Experimental Medicine&rft.volume=214&rft.spage=309&rft.date=2017 | |
dc.identifier.jtitle | Journal of Experimental Medicine | |
dc.identifier.volume | 214 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 309 | |
dc.identifier.endpage | 317 | |
dc.identifier.doi | http://dx.doi.org/10.1084/jem.20161590 | |
dc.identifier.urn | URN:NBN:no-64939 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0022-1007 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/62347/1/jem.20170057.full.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | SKGJ/SKGJ-MED-017 | |
dc.relation.project | NFR/179573 | |