Synthesis of 8-hydroxyphenanthridines employing Intramolecular Diels-Alder of Furan as the key step

Abstract

Abstract A synthetic strategy towards 8-hydroxyphenanthridines (6) was previously developed in our group, where intramolecular Diels-Alder of furan (IMDAF) was the key step. This was a continuation of a previous work as well. This strategy turned out to be not very efficient and a new and more robust strategy was planned out. The new strategy doesn’t involve diastereomers and is focused on obtaining 8- hydroxyphenanthridines in high yields, which later on can be explored for a fully functionalized ring c.