dc.date.accessioned | 2017-10-19T13:11:46Z | |
dc.date.available | 2017-10-19T13:11:46Z | |
dc.date.created | 2015-07-09T12:54:44Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Viktorsson, Elvar Örn Åstrand, Ove Alexander Høgmoen Haseeb, Rasha Sabah Gorbitz, Carl Henrik Rongved, Pål . Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,-17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,-12,13,14,15,16,17-tetradecahydro-1 H-cyclopenta-[a]phenanthren-17-yl]-N-methoxy-N-methylpro-panamide (Fernholz Weinreb amide). Acta Crystallographica Section E: Structure Reports Online. 2015, 71(3), 275-277 | |
dc.identifier.uri | http://hdl.handle.net/10852/58867 | |
dc.description.abstract | The literature compound 3[beta]-hydroxy-bisnor-5-cholenic aldehyde is an important intermediate for the synthesis of new modulators of the nuclear oxysterol receptor Liver X. As part of our ongoing search for new LXR antagonists, the title compound, C24H39NO3, has proven to be an important intermediate in our new synthetic pathway, giving the corresponding aldehyde in high yield and in only three steps from the commercially available 3[beta]-hydroxy-bisnor-5-cholenic acid. The title amide crystallized with two molecules in the asymmetric unit, linked into helices by O-H...O hydrogen bonds involving the hydroxy and carbonyl groups. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | International Union of Crystallography | |
dc.rights | Attribution 2.0 Generic | |
dc.rights.uri | https://creativecommons.org/licenses/by/2.0/ | |
dc.title | Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,-17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,-12,13,14,15,16,17-tetradecahydro-1 H-cyclopenta-[a]phenanthren-17-yl]-N-methoxy-N-methylpro-panamide (Fernholz Weinreb amide) | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Viktorsson, Elvar Örn | |
dc.creator.author | Åstrand, Ove Alexander Høgmoen | |
dc.creator.author | Haseeb, Rasha Sabah | |
dc.creator.author | Gorbitz, Carl Henrik | |
dc.creator.author | Rongved, Pål | |
cristin.unitcode | 185,15,23,20 | |
cristin.unitname | Farmasøytisk kjemi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 0 | |
dc.identifier.cristin | 1253215 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta Crystallographica Section E: Structure Reports Online&rft.volume=71&rft.spage=275&rft.date=2015 | |
dc.identifier.jtitle | Acta Crystallographica Section E: Structure Reports Online | |
dc.identifier.volume | 71 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 275 | |
dc.identifier.endpage | 277 | |
dc.identifier.doi | http://dx.doi.org/10.1107/S2056989015001747 | |
dc.identifier.urn | URN:NBN:no-61737 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1600-5368 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/58867/2/hb7343.pdf | |
dc.type.version | PublishedVersion | |