dc.date.accessioned | 2017-09-23T16:30:22Z | |
dc.date.available | 2017-09-23T16:30:22Z | |
dc.date.created | 2017-09-14T13:51:25Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Edwards, Christina De Blasio, Birgitte Freiesleben Valcarcel Salamanca, Beatriz Flem, Elmira . Re–evaluation of the cost–effectiveness and effects of childhood rotavirus vaccination in Norway. PLoS ONE. 2017, 12(8) | |
dc.identifier.uri | http://hdl.handle.net/10852/58494 | |
dc.description.abstract | Background: Rotavirus vaccination was included into the Norwegian childhood immunisation programme in 2014. Before implementation, rotavirus vaccination was found to be cost–effective from a societal perspective, but not from a healthcare perspective. Since introduction, new data on the incidence and economic effects of rotavirus disease have become available. We assessed early epidemiological effects of the rotavirus vaccination programme and re–evaluated its cost–effectiveness in Norway for the years 2015–2019.
Methods: Using a dynamic transmission model, we compared the epidemiological effects of the ongoing two–dose vaccination programme with Rotarix®, and a hypothetical 3–dose programme with RotaTeq® with no vaccination. A baseline cost of € 54 per fully vaccinated child was used. Cost–effectiveness was computed from a healthcare and societal perspective, using a decision analytical model. Data on healthcare use and costs, productivity losses and health utilities were based on published and own estimates. Uncertainty was accounted for in one–way, multi–way, and probabilistic sensitivity analyses.
Results: During 2015–2019, 114,658 home care cases, 34,571 primary care cases, 7,381 severe cases, and 2 deaths associated with rotavirus disease were avoided due to vaccination. Under baseline assumptions vaccination was cost–effective from a healthcare perspective with a cost per QALY of € 47,447 for Rotarix® and € 52,709 for RotaTeq®. The break–even price was € 70 for Rotarix® and € 67 for RotaTeq®. Vaccination was cost–saving from the societal perspective, and also from a healthcare perspective for vaccine prices below € 25 and € 22 per vaccinated child for Rotarix® and RotaTeq®, respectively. | en_US |
dc.language | EN | |
dc.publisher | Public Library of Science (PLoS) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Re–evaluation of the cost–effectiveness and effects of childhood rotavirus vaccination in Norway | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Edwards, Christina | |
dc.creator.author | De Blasio, Birgitte Freiesleben | |
dc.creator.author | Valcarcel Salamanca, Beatriz | |
dc.creator.author | Flem, Elmira | |
cristin.unitcode | 185,51,15,0 | |
cristin.unitname | Avdeling for biostatistikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1493792 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=12&rft.spage=&rft.date=2017 | |
dc.identifier.jtitle | PLoS ONE | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 8 | |
dc.identifier.pagecount | 19 | |
dc.identifier.doi | http://dx.doi.org/10.1371/journal. pone.0183306 | |
dc.identifier.urn | URN:NBN:no-61193 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-6203 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/58494/2/Edwards_2017_Ree.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e0183306 | |