dc.date.accessioned | 2017-08-09T11:20:41Z | |
dc.date.available | 2017-08-09T11:20:41Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://hdl.handle.net/10852/56921 | |
dc.description.abstract | Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in pericyte-like cells along intracerebral microvessels. Activation of HCAR1 enhances cerebral vascular endothelial growth factor A (VEGFA) and cerebral angiogenesis. High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. In contrast, skeletal muscle shows no vascular HCAR1 expression and no HCAR1-dependent change in vascularization induced by exercise or lactate. Thus, we demonstrate that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor. | en_US |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Morland, Cecilie | |
dc.creator.author | Andersson, Krister | |
dc.creator.author | Haugen, Øyvind Pernell | |
dc.creator.author | Hadzig, Alena | |
dc.creator.author | Kleppa, Liv | |
dc.creator.author | Gille, Andreas | |
dc.creator.author | Rinholm, Johanne Egge | |
dc.creator.author | Palibrk, Vuk | |
dc.creator.author | Diget, Elisabeth Holm | |
dc.creator.author | Kennedy, Lauritz Hagen | |
dc.creator.author | Stølen, Tomas | |
dc.creator.author | Hennestad, Olve | |
dc.creator.author | Cai, Yiging | |
dc.creator.author | Puchades, Maja Amedjkouh | |
dc.creator.author | Offermanns, Stefan | |
dc.creator.author | Vervaeke, Koen Gerard Alois | |
dc.creator.author | Bjørås, Magnar | |
dc.creator.author | Wisløff, Ulrik | |
dc.creator.author | Storm-Mathisen, Jon | |
dc.creator.author | Bergersen, Linda Hildegard | |
dc.identifier.cristin | 1483542 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 8 | |
dc.identifier.doi | 10.1038/ncomms15557 | |
dc.identifier.urn | URN:NBN:no-59564 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/56921/1/ncomms15557.pdf | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/56921/2/ncomms15557-supplementary.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 15557 | |