dc.date.accessioned | 2017-06-26T13:04:48Z | |
dc.date.available | 2017-06-26T13:04:48Z | |
dc.date.created | 2015-08-03T17:14:39Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Brix, Maiken Kirkegaard Ersland, Lars Hugdahl, Kenneth Grüner, Renate Posserud, Maj-Britt Rocio Hammar, Åsa Craig-Craven, Alexander Richard Noeske, Ralph Evans, C. John Walker, Hanne Bjørg Hansen Midtvedt, Tore Beyer, Mona K. . Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited. Frontiers in Human Neuroscience. 2015, 9(365), 1-12 | |
dc.identifier.uri | http://hdl.handle.net/10852/55721 | |
dc.description.abstract | Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels. | en_US |
dc.language | EN | |
dc.publisher | Frontiers Research Foundation | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Brix, Maiken Kirkegaard | |
dc.creator.author | Ersland, Lars | |
dc.creator.author | Hugdahl, Kenneth | |
dc.creator.author | Grüner, Renate | |
dc.creator.author | Posserud, Maj-Britt Rocio | |
dc.creator.author | Hammar, Åsa | |
dc.creator.author | Craig-Craven, Alexander Richard | |
dc.creator.author | Noeske, Ralph | |
dc.creator.author | Evans, C. John | |
dc.creator.author | Walker, Hanne Bjørg Hansen | |
dc.creator.author | Midtvedt, Tore | |
dc.creator.author | Beyer, Mona K. | |
cristin.unitcode | 185,15,29,0 | |
cristin.unitname | Institutt for biovitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1256151 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers in Human Neuroscience&rft.volume=9&rft.spage=1&rft.date=2015 | |
dc.identifier.jtitle | Frontiers in Human Neuroscience | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 365 | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 12 | |
dc.identifier.doi | http://dx.doi.org/10.3389/fnhum.2015.00365 | |
dc.identifier.urn | URN:NBN:no-58478 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1662-5161 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/55721/1/fnhum-09-00365.pdf | |
dc.type.version | PublishedVersion | |