dc.date.accessioned | 2017-06-26T11:10:57Z | |
dc.date.available | 2017-06-26T11:10:57Z | |
dc.date.created | 2016-12-20T15:17:59Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Berg, Anna Fasmer, Kristine Eldevik Mauland, Karen Klepsland Ytre-Hauge, Sigmund Høivik, Erling Andre Husby, Jenny Hild Aase Tangen, Ingvild Løberg Trovik, Jone Halle, Mari Kyllesø Woie, Kathrine Bjørge, Line Bjørnerud, Atle Salvesen, Helga Werner, Henrica Maria Johanna Krakstad, Camilla Haldorsen, Ingfrid S. . Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer. OncoTarget. 2016, 7(43), 69844-69856 | |
dc.identifier.uri | http://hdl.handle.net/10852/55706 | |
dc.description.abstract | Hypoxia is frequent in solid tumors and linked to aggressive phenotypes and therapy resistance. We explored expression patterns of the proposed hypoxia marker HIF-1α in endometrial cancer (EC) and investigate whether preoperative functional imaging parameters are associated with tumor hypoxia. Expression of HIF-1α was explored both in the epithelial and the stromal tumor component. We found that low epithelial HIF-1α and high stromal HIF-1α expression were significantly associated with reduced disease specific survival in EC. Only stromal HIF-1α had independent prognostic value in Cox regression analysis. High stromal HIF-1α protein expression was rare in the premalignant lesions of complex atypical hyperplasia but increased significantly to invasive cancer. High stromal HIF-1α expression was correlated with overexpression of important genes downstream from HIF-1α, i.e. VEGFA and SLC2A1 (GLUT1). Detecting hypoxic tumors with preoperative functional imaging might have therapeutic benefits. We found that high stromal HIF-1α expression associated with high total lesion glycolysis (TLG) at PET/CT. High expression of a gene signature linked to hypoxia also correlated with low tumor blood flow at DCE-MRI and increased metabolism measured by FDG-PET. PI3K pathway inhibitors were identified as potential therapeutic compounds in patients with lesions overexpressing this gene signature. In conclusion, we show that high stromal HIF-1α expression predicts reduced survival in EC and is associated with increased tumor metabolism at FDG-PET/CT. Importantly; we demonstrate a correlation between tissue and imaging biomarkers reflecting hypoxia, and also possible treatment targets for selected patients. | en_US |
dc.language | EN | |
dc.publisher | Impact Journals LLC | |
dc.rights | Attribution 3.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.title | Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Berg, Anna | |
dc.creator.author | Fasmer, Kristine Eldevik | |
dc.creator.author | Mauland, Karen Klepsland | |
dc.creator.author | Ytre-Hauge, Sigmund | |
dc.creator.author | Høivik, Erling Andre | |
dc.creator.author | Husby, Jenny Hild Aase | |
dc.creator.author | Tangen, Ingvild Løberg | |
dc.creator.author | Trovik, Jone | |
dc.creator.author | Halle, Mari Kyllesø | |
dc.creator.author | Woie, Kathrine | |
dc.creator.author | Bjørge, Line | |
dc.creator.author | Bjørnerud, Atle | |
dc.creator.author | Salvesen, Helga | |
dc.creator.author | Werner, Henrica Maria Johanna | |
dc.creator.author | Krakstad, Camilla | |
dc.creator.author | Haldorsen, Ingfrid S. | |
cristin.unitcode | 185,15,4,50 | |
cristin.unitname | Biofysikk og medisinsk fysikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1415811 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=OncoTarget&rft.volume=7&rft.spage=69844&rft.date=2016 | |
dc.identifier.jtitle | OncoTarget | |
dc.identifier.volume | 7 | |
dc.identifier.issue | 43 | |
dc.identifier.startpage | 69844 | |
dc.identifier.endpage | 69856 | |
dc.identifier.doi | http://dx.doi.org/10.18632/oncotarget.12004 | |
dc.identifier.urn | URN:NBN:no-58474 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1949-2553 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/55706/1/12004-180776-3-PB.pdf | |
dc.type.version | PublishedVersion | |