dc.date.accessioned | 2017-04-20T14:25:13Z | |
dc.date.available | 2017-04-20T14:25:13Z | |
dc.date.created | 2016-08-30T14:16:11Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Bårnes, Guro Kristine Workalemahu, Bereket Kristiansen, Paul Arne Beyene, Demissew Balcha Merdekios, Behailu Fissiha, P. Aseffa, Abraham Caugant, Dominique A Næss, Lisbeth Meyer . Salivary and serum antibody response against Neisseria meningitidis after vaccination with conjugate polysaccharide vaccines in Ethiopian volunteers. Scandinavian Journal of Immunology. 2016, 84(2), 118-129 | |
dc.identifier.uri | http://hdl.handle.net/10852/55218 | |
dc.description.abstract | Meningococcal conjugate vaccines induce serum antibodies crucial for protection against invasive disease. Salivary antibodies are believed to be important for hindering meningococcal acquisition and/or clearance of established carriage. In this study, we measured salivary IgA and IgG antibodies induced by vaccination with a monovalent serogroup A conjugate vaccine or a tetravalent A, C, W and Y conjugate vaccine, in comparison with antibody levels in serum. Saliva and serum samples from Ethiopian volunteers (1–29 years) collected before and eight times on a weekly basis after receiving the serogroup A conjugate vaccine, the tetravalent serogroup A, C, W and Y conjugate vaccine, or no vaccine (control group), were analysed using a multiplex microsphere immunoassay for antibody detection. Serogroup-specific IgG antibody levels in saliva increased significantly after vaccination with both vaccines. The monovalent serogroup A vaccine also induced an increase in salivary IgA antibodies. A strong correlation between serogroup-specific IgG antibodies in saliva and serum, and a somewhat lower correlation for IgA, was observed for all serogroups. There was also a strong correlation between specific secretory IgA and IgA antibodies in saliva for all serogroups. Meningococcal conjugate vaccines are able to elicit salivary antibodies against serogroup A, C, W and Y correlating with antibody levels in serum. The strong correlation between saliva and serum antibody levels indicates that saliva may be used as a surrogate of systemic antibody responses. | en_US |
dc.language | EN | |
dc.publisher | Blackwell Scientific Publications | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Salivary and serum antibody response against Neisseria meningitidis after vaccination with conjugate polysaccharide vaccines in Ethiopian volunteers | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Bårnes, Guro Kristine | |
dc.creator.author | Workalemahu, Bereket | |
dc.creator.author | Kristiansen, Paul Arne | |
dc.creator.author | Beyene, Demissew Balcha | |
dc.creator.author | Merdekios, Behailu | |
dc.creator.author | Fissiha, P. | |
dc.creator.author | Aseffa, Abraham | |
dc.creator.author | Caugant, Dominique A | |
dc.creator.author | Næss, Lisbeth Meyer | |
cristin.unitcode | 185,52,14,0 | |
cristin.unitname | Avdeling for samfunnsmedisin og global helse | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1376697 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scandinavian Journal of Immunology&rft.volume=84&rft.spage=118&rft.date=2016 | |
dc.identifier.jtitle | Scandinavian Journal of Immunology | |
dc.identifier.volume | 84 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 118 | |
dc.identifier.endpage | 129 | |
dc.identifier.doi | http://dx.doi.org/10.1111/sji.12451 | |
dc.identifier.urn | URN:NBN:no-58020 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0300-9475 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/55218/1/Baarnes_2016_Sal.pdf | |
dc.type.version | PublishedVersion | |