dc.date.accessioned | 2017-04-06T14:04:29Z | |
dc.date.available | 2017-04-06T14:04:29Z | |
dc.date.created | 2016-05-30T12:27:06Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Strand, Bjørn Heine Cooper, Rachel Bergland, Astrid Jørgensen, Lone Schirmer, Henrik Skirbekk, Vegard Emaus, Nina . The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study. Journal of Epidemiology and Community Health. 2016, 70(12), 1214-1221 | |
dc.identifier.uri | http://hdl.handle.net/10852/55177 | |
dc.description.abstract | Background
Grip strength has consistently been found to predict all-cause mortality rates. However, few studies have examined cause-specific mortality or tested age differences in these associations.
Methods
In 1994, grip strength was measured in the population-based Tromsø Study, covering the ages 50–80 years (N=6850). Grip strength was categorised into fifths, and as z-scores. In this cohort study, models with all-cause mortality and deaths from specific causes as the outcome were performed, stratified by sex and age using Cox regression, adjusting for lifestyle-related and health-related factors.
Results
During 17 years of follow-up, 2338 participants died. A 1 SD reduction in grip strength was associated with HR=1.17 (95% CI 1.12 to 1.22) for all-cause mortality in a model adjusted for age, gender and body size. This association was similar across all age groups, in men and women, and robust to adjustment for a range of lifestyle-related and health-related factors. Results for deaths due to cardiovascular disease (CVD), respiratory diseases and external causes resembled those for all-cause mortality, while for cancer, the association was much weaker and not significant after adjustment for lifestyle-related and health-related factors.
Conclusions
Weaker grip strength was associated with increased all-cause mortality rates, with similar effects on deaths due to CVD, respiratory disease and external causes, while a much weaker association was observed for cancer-related deaths. These associations were similar in both genders and across age groups, which supports the hypothesis that grip strength might be a biomarker of ageing over the lifespan. | en_US |
dc.language | EN | |
dc.publisher | BMJ Group | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Strand, Bjørn Heine | |
dc.creator.author | Cooper, Rachel | |
dc.creator.author | Bergland, Astrid | |
dc.creator.author | Jørgensen, Lone | |
dc.creator.author | Schirmer, Henrik | |
dc.creator.author | Skirbekk, Vegard | |
dc.creator.author | Emaus, Nina | |
cristin.unitcode | 185,52,14,0 | |
cristin.unitname | Avdeling for samfunnsmedisin og global helse | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1358336 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Epidemiology and Community Health&rft.volume=70&rft.spage=1214&rft.date=2016 | |
dc.identifier.jtitle | Journal of Epidemiology and Community Health | |
dc.identifier.volume | 70 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 1214 | |
dc.identifier.endpage | 1221 | |
dc.identifier.doi | http://dx.doi.org/10.1136/jech-2015-206776 | |
dc.identifier.urn | URN:NBN:no-57977 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0143-005X | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/55177/1/Strand_2016_The.pdf | |
dc.type.version | PublishedVersion | |