dc.date.accessioned | 2017-03-02T14:36:17Z | |
dc.date.available | 2017-03-02T14:36:17Z | |
dc.date.created | 2015-02-08T20:31:44Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Sand, Kine Marita Knudsen Bern, Malin C. Nilsen, Jeannette Noordzij, Hanna Theodora Sandlie, Inger Andersen, Jan Terje . Unraveling the interaction between FcRn and albumin: Opportunities for design of albumin-based therapeutics. Frontiers in Immunology. 2015, 5:682 | |
dc.identifier.uri | http://hdl.handle.net/10852/54159 | |
dc.description.abstract | The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for protecting IgG from intracellular catabolism. However, it has now become apparent that the same receptor also binds albumin and plays a fundamental role in homeostatic regulation of both IgG and albumin, as FcRn is expressed in many different cell types and organs at diverse body sites. Thus, to gain a complete understanding of the biological function of each ligand, and also their distribution in the body, an in-depth characterization of how FcRn binds and regulates the transport of both ligands is necessary. Importantly, such knowledge is also relevant when developing new drugs, as IgG and albumin are increasingly utilized in therapy. This review discusses our current structural and biological understanding of the relationship between FcRn and its ligands, with a particular focus on albumin and design of albumin-based therapeutics. | en_US |
dc.language | EN | |
dc.publisher | Frontiers Research Foundation | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Unraveling the interaction between FcRn and albumin: Opportunities for design of albumin-based therapeutics | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Sand, Kine Marita Knudsen | |
dc.creator.author | Bern, Malin C. | |
dc.creator.author | Nilsen, Jeannette | |
dc.creator.author | Noordzij, Hanna Theodora | |
dc.creator.author | Sandlie, Inger | |
dc.creator.author | Andersen, Jan Terje | |
cristin.unitcode | 185,53,2,11 | |
cristin.unitname | Senter for immunregulering | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1218661 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers in Immunology&rft.volume=5:682&rft.spage=&rft.date=2015 | |
dc.identifier.jtitle | Frontiers in Immunology | |
dc.identifier.volume | 5 | |
dc.identifier.doi | http://dx.doi.org/10.3389/fimmu.2014.00682 | |
dc.identifier.urn | URN:NBN:no-57281 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1664-3224 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/54159/1/9.%2Bfimmu-05-00682.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 682 | |