dc.date.accessioned | 2017-01-30T14:23:20Z | |
dc.date.available | 2017-01-30T14:23:20Z | |
dc.date.created | 2017-01-26T08:59:22Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Vrbanec, Jurica Lederer-Dembic, Petra Bulat-Kardum, Ljiljana Balen, Sanja Eftedal, Randi Krog Dembic, Zlatko . Genetic Risk of Tuberculosis is Spread within the Hallmarks of the Disease. Immunotherapy: Open Access. 2016, 2(2), 117-122 | |
dc.identifier.uri | http://hdl.handle.net/10852/53631 | |
dc.description.abstract | Regarding genetic predisposition to tuberculosis, we suggest that the maximal risk for clinical manifestation requires complementation of sub-risks divided among the hallmarks of the disease. Clinical tuberculosis would only be revealed if at least one from each group of the genes encoding putative 5 (perhaps 7) hallmarks of the disease are mutated or changed epigenetically. These mutations/changes could be either sporadic (usually by the influence of the environment like other infection [HIV], nutrition, smoking, radiation etc.) or inherited. Avoidance of the immune attack is one of the hallmarks for TB that is shared with cancer. Perhaps, a similar immunotherapy as the recent one used in treating immunogenic types of cancer (anti-PD1, or/and anti-CTLA4) could be also successful in therapy of (multi-drug) resistant TB.
© 2016 Vrbanec J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.title | Genetic Risk of Tuberculosis is Spread within the Hallmarks of the Disease | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Vrbanec, Jurica | |
dc.creator.author | Lederer-Dembic, Petra | |
dc.creator.author | Bulat-Kardum, Ljiljana | |
dc.creator.author | Balen, Sanja | |
dc.creator.author | Eftedal, Randi Krog | |
dc.creator.author | Dembic, Zlatko | |
cristin.unitcode | 185,16,0,0 | |
cristin.unitname | Det odontologiske fakultet | |
cristin.ispublished | true | |
cristin.fulltext | original | |
dc.identifier.cristin | 1437957 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Immunotherapy: Open Access&rft.volume=2&rft.spage=117&rft.date=2016 | |
dc.identifier.jtitle | Immunotherapy: Open Access | |
dc.identifier.volume | 2 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 117 | |
dc.identifier.endpage | 122 | |
dc.identifier.doi | http://dx.doi.org/10.4172/2471-9552.1000117 | |
dc.identifier.urn | URN:NBN:no-56805 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2471-9552 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/53631/2/genetic-risk-of-tuberculosis-is-spread-within-the-hallmarks-of-t.pdf | |
dc.type.version | PublishedVersion | |