dc.date.accessioned | 2016-08-18T10:49:31Z | |
dc.date.available | 2016-08-18T10:49:31Z | |
dc.date.created | 2016-04-18T18:51:49Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Heggelund, Julie Elisabeth Burschowsky, Daniel Bjørnestad, Victoria Ariel Hodnik, Vesna Anderluh, Gregor Krengel, Ute . High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence. PLoS Pathogens. 2016, 12(4), e1005567 | |
dc.identifier.uri | http://hdl.handle.net/10852/51284 | |
dc.description.abstract | Cholera is the prime example of blood-group-dependent diseases, with individuals of blood group O experiencing the most severe symptoms. The cholera toxin is the main suspect to cause this relationship. We report the high-resolution crystal structures (1.1–1.6 Å) of the native cholera toxin B-pentamer for both classical and El Tor biotypes, in complexes with relevant blood group determinants and a fragment of its primary receptor, the GM1 ganglioside. The blood group A determinant binds in the opposite orientation compared to previously published structures of the cholera toxin, whereas the blood group H determinant, characteristic of blood group O, binds in both orientations. H-determinants bind with higher affinity than A-determinants, as shown by surface plasmon resonance. Together, these findings suggest why blood group O is a risk factor for severe cholera. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science (PLoS) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Heggelund, Julie Elisabeth | |
dc.creator.author | Burschowsky, Daniel | |
dc.creator.author | Bjørnestad, Victoria Ariel | |
dc.creator.author | Hodnik, Vesna | |
dc.creator.author | Anderluh, Gregor | |
dc.creator.author | Krengel, Ute | |
cristin.unitcode | 185,15,12,51 | |
cristin.unitname | Biologisk kjemi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1351085 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS Pathogens&rft.volume=12&rft.spage=e1005567&rft.date=2016 | |
dc.identifier.jtitle | PLoS Pathogens | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 4 | |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.ppat.1005567 | |
dc.identifier.urn | URN:NBN:no-54729 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1553-7366 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/51284/1/journal-ppat-1005567.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e1005567 | |